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GPR135 G protein-coupled receptor 135 [ Homo sapiens (human) ]

Gene ID: 64582, updated on 22-Sep-2022

Summary

Official Symbol
GPR135provided by HGNC
Official Full Name
G protein-coupled receptor 135provided by HGNC
Primary source
HGNC:HGNC:19991
See related
Ensembl:ENSG00000181619 MIM:607970; AllianceGenome:HGNC:19991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUMNPIIY20
Summary
Enables arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 3.7), ovary (RPKM 1.1) and 20 other tissues See more
Orthologs
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Genomic context

See GPR135 in Genome Data Viewer
Location:
14q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (59452783..59465380, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (53667678..53672299, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59927477..59932098, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984642 Neighboring gene peptidylprolyl isomerase A pseudogene 5 Neighboring gene dishevelled associated activator of morphogenesis 1 Neighboring gene uncharacterized LOC124903326 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene JNK1/MAPK8 associated membrane protein Neighboring gene coiled-coil domain containing 175

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of G protein-coupled receptor 135 (GPR135) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arrestin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 135
Names
probable G-protein coupled receptor 135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022571.6NP_072093.2  G-protein coupled receptor 135

    See identical proteins and their annotated locations for NP_072093.2

    Status: VALIDATED

    Source sequence(s)
    AL159140, AY288418, BC032831, BX094623
    Consensus CDS
    CCDS9738.1
    UniProtKB/Swiss-Prot
    Q8IZ08, Q8NH39
    Related
    ENSP00000378548.1, ENST00000395116.2
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    59452783..59465380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021599.3XP_016877088.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_017021598.3XP_016877087.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_024449696.2XP_024305464.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_024449695.2XP_024305463.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_024449694.2XP_024305462.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q8NH39
    Related
    ENSP00000432696.1, ENST00000481661.1
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_024449693.2XP_024305461.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_017021596.3XP_016877085.1  G-protein coupled receptor 135 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZ08, Q8NH39
    Conserved Domains (2) summary
    cd14964
    Location:139161
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:120398
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    53667678..53672299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)