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Sirt3 sirtuin 3 [ Mus musculus (house mouse) ]

Gene ID: 64384, updated on 27-Feb-2024

Summary

Official Symbol
Sirt3provided by MGI
Official Full Name
sirtuin 3provided by MGI
Primary source
MGI:MGI:1927665
See related
Ensembl:ENSMUSG00000025486 AllianceGenome:MGI:1927665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2l3; 2310003L23Rik
Summary
Enables NAD-dependent histone deacetylase activity (H3-K14 specific) and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation and protein deacetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 35.3), liver adult (RPKM 33.7) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt3 in Genome Data Viewer
Location:
7 F4- F5; 7 86.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140443576..140462222, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140863663..140882309, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule associated protein 1A Neighboring gene STARR-positive B cell enhancer ABC_E1748 Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene STARR-positive B cell enhancer ABC_E9304 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene cytochrome c oxidase subunit 8B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD-dependent histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-lysine deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of catalase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-3
Names
NAD-dependent deacetylase sirtuin-3
SIR2-like protein 3
SIRT3L mitochondrial
mSIR2L3
mitochondrial protein lysine deacetylase
regulatory protein SIR2 homolog 3
silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3
NP_001120823.1
NP_001171275.1
NP_071878.2
XP_006536285.1
XP_006536286.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127351.1NP_001120823.1  NAD-dependent protein deacetylase sirtuin-3 isoform 1

    See identical proteins and their annotated locations for NP_001120823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.
    Source sequence(s)
    AF299338, AF299339, BF681854, CT010402
    Consensus CDS
    CCDS21989.1
    UniProtKB/TrEMBL
    A0A1B0GRY5, Q4FJK3
    Related
    ENSMUSP00000101663.4, ENSMUST00000106048.10
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_001177804.1NP_001171275.1  NAD-dependent protein deacetylase sirtuin-3 isoform 3

    See identical proteins and their annotated locations for NP_001171275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (2).
    Source sequence(s)
    AK075861, BF681854, CB953804
    UniProtKB/Swiss-Prot
    B9W0A9, C6ZII7, Q8R104, Q9EPA8
    Conserved Domains (1) summary
    cd01408
    Location:74308
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  3. NM_022433.2NP_071878.2  NAD-dependent protein deacetylase sirtuin-3 isoform 1

    See identical proteins and their annotated locations for NP_071878.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5' exon and an additional segment, resulting in a downstream AUG start codon, as compared to variant 3. The resulting isoform (1) is shorter at the N-terminus, as compared to isoform 2.
    Source sequence(s)
    AF299338, BF681854, CT010402
    Consensus CDS
    CCDS21989.1
    UniProtKB/TrEMBL
    A0A1B0GRY5, Q4FJK3
    Related
    ENSMUSP00000026559.8, ENSMUST00000026559.14
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140443576..140462222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536222.5XP_006536285.1  NAD-dependent protein deacetylase sirtuin-3 isoform X1

    UniProtKB/TrEMBL
    D3YTK6
    Conserved Domains (1) summary
    cl00195
    Location:74254
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. XM_006536223.5XP_006536286.1  NAD-dependent protein deacetylase sirtuin-3 isoform X2

    See identical proteins and their annotated locations for XP_006536286.1

    UniProtKB/TrEMBL
    D3YVQ5
    Related
    ENSMUSP00000114247.2, ENSMUST00000137024.8
    Conserved Domains (1) summary
    cl00195
    Location:1177
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...