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SIRT3 sirtuin 3 [ Homo sapiens (human) ]

Gene ID: 23410, updated on 20-Sep-2020

Summary

Official Symbol
SIRT3provided by HGNC
Official Full Name
sirtuin 3provided by HGNC
Primary source
HGNC:HGNC:14931
See related
Ensembl:ENSG00000142082 MIM:604481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L3
Summary
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
Expression
Ubiquitous expression in testis (RPKM 6.7), brain (RPKM 5.6) and 25 other tissues See more
Orthologs

Genomic context

See SIRT3 in Genome Data Viewer
Location:
11p15.5
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (215030..236931, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (215030..236362, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene microRNA 6743 Neighboring gene proteasome 26S subunit, non-ATPase 13 Neighboring gene signal recognition particle 19kDa pseudogene Neighboring gene cytochrome c oxidase subunit 8B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
GeneReviews: Not available
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.
GeneReviews: Not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent protein deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization TAS
Traceable Author Statement
more info
 
negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of catalase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein ADP-ribosylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Names
NAD-dependent deacetylase sirtuin-3, mitochondrial
SIR2-like protein 3
mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
regulatory protein SIR2 homolog 3
silent mating type information regulation 2, S.cerevisiae, homolog 3
sir2-like 3
sirtuin type 3
NP_001017524.1
NP_001357239.1
NP_001357241.1
NP_001357243.1
NP_001357244.1
NP_001357245.1
NP_001357246.1
NP_001357247.1
NP_001357248.1
NP_001357249.1
NP_001357250.1
NP_001357251.1
NP_001357252.1
NP_001357253.1
NP_001357254.1
NP_036371.1
XP_011518258.1
XP_011518259.1
XP_016872920.1
XP_024304178.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017524.3NP_001017524.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001017524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' end which causes the use of a downstream start codon, compared to variant 1. The resulting protein (isoform b) is shorter at the N-terminus compared to isoform a. Variants 2 and 9-11 all encode the same isoform (b).
    Source sequence(s)
    AC069287, AI091200, AL535769, BC001042, BI755839, BM973763, DR762907
    Consensus CDS
    CCDS53590.1
    UniProtKB/Swiss-Prot
    Q9NTG7
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  2. NM_001370310.1NP_001357239.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (c).
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cd01408
    Location:138373
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  3. NM_001370312.1NP_001357241.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform d

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475, AK301558
    Related
    ENSP00000432937.1, ENST00000524564.5
    Conserved Domains (1) summary
    cd01408
    Location:88309
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  4. NM_001370314.1NP_001357243.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform e

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475, AK299009
    Related
    ENSP00000433077.1, ENST00000532956.5
    Conserved Domains (1) summary
    cl00195
    Location:138319
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  5. NM_001370315.1NP_001357244.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475, AK298572
    Related
    ENSP00000435464.1, ENST00000525319.5
    Conserved Domains (1) summary
    cd01408
    Location:57292
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  6. NM_001370316.1NP_001357245.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cl00195
    Location:46149
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  7. NM_001370317.1NP_001357246.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform h

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475, HY006161
    Conserved Domains (1) summary
    cl00195
    Location:1101
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  8. NM_001370318.1NP_001357247.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 2, 10, and 11, encodes isoform b.
    Source sequence(s)
    AC069287, AC136475
    Related
    ENSP00000437216.1, ENST00000529382.5
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  9. NM_001370319.1NP_001357248.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 2, 9, and 11, encodes isoform b.
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  10. NM_001370320.1NP_001357249.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 2, 9, and 10, encodes isoform b.
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  11. NM_001370321.1NP_001357250.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform i.
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  12. NM_001370322.1NP_001357251.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform i.
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  13. NM_001370323.1NP_001357252.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform i.
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  14. NM_001370324.1NP_001357253.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform j.
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cl00195
    Location:1181
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  15. NM_001370325.1NP_001357254.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform j.
    Source sequence(s)
    AC069287, AC136475
    Conserved Domains (1) summary
    cl00195
    Location:1181
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  16. NM_012239.6NP_036371.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_036371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC069287, AI091200, AL535769, BC001042, BM973763, DR762907
    Consensus CDS
    CCDS7691.1
    UniProtKB/Swiss-Prot
    Q9NTG7
    Related
    ENSP00000372191.4, ENST00000382743.9
    Conserved Domains (1) summary
    cd01408
    Location:138373
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RNA

  1. NR_163386.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  2. NR_163387.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  3. NR_163388.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  4. NR_163389.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  5. NR_163390.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  6. NR_163391.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  7. NR_163392.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  8. NR_163393.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  9. NR_163394.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  10. NR_163395.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  11. NR_163396.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  12. NR_163397.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  13. NR_163398.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  14. NR_163399.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  15. NR_163400.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  16. NR_163401.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475
  17. NR_163402.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC069287, AC136475

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    215030..236931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017431.1XP_016872920.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  2. XM_011519956.2XP_011518258.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011518258.1

    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  3. XM_024448410.1XP_024304178.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
  4. XM_011519957.2XP_011518259.1  NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011518259.1

    Conserved Domains (1) summary
    cd01408
    Location:1231
    SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
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