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TMEM253 transmembrane protein 253 [ Homo sapiens (human) ]

Gene ID: 643382, updated on 13-May-2022

Summary

Official Symbol
TMEM253provided by HGNC
Official Full Name
transmembrane protein 253provided by HGNC
Primary source
HGNC:HGNC:32545
See related
Ensembl:ENSG00000232070 AllianceGenome:HGNC:32545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf95; C14orf176; NCRNA00220
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 26.0), small intestine (RPKM 24.6) and 2 other tissues See more
Orthologs
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Genomic context

See TMEM253 in Genome Data Viewer
Location:
14q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21098836..21103724)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15296249..15301137)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21566995..21571883)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NDRG family member 2 Neighboring gene ribonuclease A family member 8 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene zinc finger protein 219 Neighboring gene RNA, U6 small nuclear 252, pseudogene Neighboring gene cytoskeleton associated protein 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 253
Names
transmembrane protein C14orf176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146683.2NP_001140155.1  transmembrane protein 253 isoform 1

    See identical proteins and their annotated locations for NP_001140155.1

    Status: VALIDATED

    Source sequence(s)
    AL161668
    Consensus CDS
    CCDS53884.1
    UniProtKB/Swiss-Prot
    P0C7T8
    Related
    ENSP00000453962.1, ENST00000418511.6
  2. NM_001395464.1NP_001382393.1  transmembrane protein 253 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL161668
  3. NM_001395465.1NP_001382394.1  transmembrane protein 253 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL161668
  4. NM_001395466.1NP_001382395.1  transmembrane protein 253 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL161668
  5. NM_001395467.1NP_001382396.1  transmembrane protein 253 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL161668
    Related
    ENSP00000451229.2, ENST00000556585.2

RNA

  1. NR_172562.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL161668

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21098836..21103724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537078.3XP_011535380.1  transmembrane protein 253 isoform X1

    See identical proteins and their annotated locations for XP_011535380.1

    UniProtKB/Swiss-Prot
    P0C7T8
  2. XM_011537079.3XP_011535381.1  transmembrane protein 253 isoform X1

    See identical proteins and their annotated locations for XP_011535381.1

    UniProtKB/Swiss-Prot
    P0C7T8
  3. XM_011537084.3XP_011535386.1  transmembrane protein 253 isoform X3

  4. XM_011537083.3XP_011535385.1  transmembrane protein 253 isoform X2

  5. XM_047431689.1XP_047287645.1  transmembrane protein 253 isoform X5

  6. XM_011537085.3XP_011535387.1  transmembrane protein 253 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15296249..15301137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)