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FAM25A family with sequence similarity 25 member A [ Homo sapiens (human) ]

Gene ID: 643161, updated on 31-Jan-2026
Official Symbol
FAM25Aprovided by HGNC
Official Full Name
family with sequence similarity 25 member Aprovided by HGNC
Primary source
HGNC:HGNC:23436
See related
Ensembl:ENSG00000188100 AllianceGenome:HGNC:23436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
bA96C23.5
Expression
Biased expression in esophagus (RPKM 44.0) and skin (RPKM 23.0) See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See FAM25A in Genome Data Viewer
Location:
10q23.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (87020294..87024730)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (87903926..87908365)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88780051..88784487)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:88730527-88731726 Neighboring gene uncharacterized LOC124902474 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 11 Neighboring gene BMS1 pseudogene 3 Neighboring gene MPRA-validated peak1043 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88779570-88780070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88780071-88780571 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:88784270-88785122 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:88785123-88785973 Neighboring gene RNA, U6 small nuclear 529, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3703 Neighboring gene glutamate dehydrogenase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3704 Neighboring gene NANOG hESC enhancer GRCh37_chr10:88852612-88853149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2577 Neighboring gene shieldin complex subunit 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  2. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  3. Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids. Broderick K, et al. Nat Commun, 2025 Jul 1. PMID 40593736, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
protein FAM25A
Names
protein FAM25

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146157.3 → NP_001139629.1  protein FAM25A

    See identical proteins and their annotated locations for NP_001139629.1

    Status: VALIDATED

    Source sequence(s)
    AL136982
    Consensus CDS
    CCDS44451.1
    UniProtKB/Swiss-Prot
    B2RV02, B3EWG3, B3EWG5, B3EWG6, Q5VTM1
    UniProtKB/TrEMBL
    B7ZW47
    Related
    ENSP00000342790.4, ENST00000343959.5
    Conserved Domains (1) summary
    pfam15825
    Location:24 → 88
    FAM25; FAM25 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    87020294..87024730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    87903926..87908365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3EWG3.1 GenPept UniProtKB/Swiss-Prot:B3EWG3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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