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Gprc5b G protein-coupled receptor, family C, group 5, member B [ Mus musculus (house mouse) ]

Gene ID: 64297, updated on 18-Apr-2024

Summary

Official Symbol
Gprc5bprovided by MGI
Official Full Name
G protein-coupled receptor, family C, group 5, member Bprovided by MGI
Primary source
MGI:MGI:1927596
See related
Ensembl:ENSMUSG00000008734 AllianceGenome:MGI:1927596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Raig2
Summary
Enables protein kinase binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of neuron differentiation; and positive regulation of signal transduction. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of neuron projection development; and positive regulation of protein kinase activity. Located in cell surface; membrane raft; and plasma membrane. Is expressed in several structures, including alimentary system; brain; brown fat; extraembryonic component; and genitourinary system. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 63.2), frontal lobe adult (RPKM 44.6) and 17 other tissues See more
Orthologs
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Genomic context

Location:
7 F2; 7 63.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118571263..118594434, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118972040..118995211, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene STARR-seq mESC enhancer starr_20027 Neighboring gene predicted gene, 26147 Neighboring gene lysine rich nucleolar protein 1 Neighboring gene IQ motif containing K Neighboring gene STARR-seq mESC enhancer starr_20029 Neighboring gene predicted gene, 39076 Neighboring gene STARR-seq mESC enhancer starr_20031 Neighboring gene G protein-coupled receptor 139 Neighboring gene STARR-seq mESC enhancer starr_20032 Neighboring gene predicted gene 4083

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase inhibitor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
G-protein coupled receptor family C group 5 member B
Names
RAIG-2
hypothetical protein, clone 2-63
retinoic acid-induced gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195774.1NP_001182703.1  G-protein coupled receptor family C group 5 member B isoform 1 precursor

    See identical proteins and their annotated locations for NP_001182703.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC151534, CJ054496, FJ529379
    Consensus CDS
    CCDS85400.1
    UniProtKB/TrEMBL
    D2DFA9
    Related
    ENSMUSP00000146777.2, ENSMUST00000208394.2
    Conserved Domains (1) summary
    pfam00003
    Location:112293
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  2. NM_022420.2NP_071865.1  G-protein coupled receptor family C group 5 member B isoform 2 precursor

    See identical proteins and their annotated locations for NP_071865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC151534
    Consensus CDS
    CCDS21777.1
    UniProtKB/Swiss-Prot
    Q8CCV3, Q923Z0
    Related
    ENSMUSP00000008878.9, ENSMUST00000008878.10
    Conserved Domains (1) summary
    pfam00003
    Location:112293
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    118571263..118594434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)