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GPRC5B G protein-coupled receptor class C group 5 member B [ Homo sapiens (human) ]

Gene ID: 51704, updated on 2-Oct-2018

Summary

Official Symbol
GPRC5Bprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Bprovided by HGNC
Primary source
HGNC:HGNC:13308
See related
Ensembl:ENSG00000167191 MIM:605948; Vega:OTTHUMG00000131460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAIG2; RAIG-2
Summary
This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in brain (RPKM 139.6), testis (RPKM 34.2) and 11 other tissues See more
Orthologs

Genomic context

See GPRC5B in Genome Data Viewer
Location:
16p12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (19858971..19886045, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19870293..19897049, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene IQ motif containing K Neighboring gene uncharacterized LOC105371115 Neighboring gene La ribonucleoprotein domain family member 7 pseudogene 2 Neighboring gene uncharacterized LOC105371116 Neighboring gene uncharacterized LOC105371117

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
locomotory behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macrophage cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of macrophage cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor family C group 5 member B
Names
G protein-coupled receptor, family C, group 1, member B
retinoic acid responsive gene protein
retinoic acid-induced gene 2 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304771.1NP_001291700.1  G-protein coupled receptor family C group 5 member B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in the use of an upstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AK302838, AL137684, DC344063
    UniProtKB/TrEMBL
    B7Z831
    Conserved Domains (1) summary
    pfam00003
    Location:243424
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
  2. NM_016235.2NP_057319.1  G-protein coupled receptor family C group 5 member B isoform 1 precursor

    See identical proteins and their annotated locations for NP_057319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC034467, BI462652, DA141861
    Consensus CDS
    CCDS10581.1
    UniProtKB/Swiss-Prot
    Q9NZH0
    UniProtKB/TrEMBL
    A0A024QYX2
    Related
    ENSP00000300571.2, OTTHUMP00000162164, ENST00000300571.6, OTTHUMT00000254285
    Conserved Domains (1) summary
    cd15278
    Location:54297
    7tmC_RAIG2_GPRC5B; retinoic acid-inducible orphan G-protein-coupled receptor 2; class C family of seven-transmembrane G protein-coupled receptors, group 5, member B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    19858971..19886045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721052.2XP_006721115.1  G-protein coupled receptor family C group 5 member B isoform X1

    See identical proteins and their annotated locations for XP_006721115.1

    UniProtKB/Swiss-Prot
    Q9NZH0
    UniProtKB/TrEMBL
    A0A024QYX2
    Related
    ENSP00000454727.1, OTTHUMP00000256250, ENST00000569479.5, OTTHUMT00000436047
    Conserved Domains (1) summary
    cd15278
    Location:54297
    7tmC_RAIG2_GPRC5B; retinoic acid-inducible orphan G-protein-coupled receptor 2; class C family of seven-transmembrane G protein-coupled receptors, group 5, member B
  2. XM_006721051.3XP_006721114.1  G-protein coupled receptor family C group 5 member B isoform X1

    See identical proteins and their annotated locations for XP_006721114.1

    UniProtKB/Swiss-Prot
    Q9NZH0
    UniProtKB/TrEMBL
    A0A024QYX2
    Related
    ENSP00000457283.1, ENST00000569847.1
    Conserved Domains (1) summary
    cd15278
    Location:54297
    7tmC_RAIG2_GPRC5B; retinoic acid-inducible orphan G-protein-coupled receptor 2; class C family of seven-transmembrane G protein-coupled receptors, group 5, member B
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