U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TENT4B terminal nucleotidyltransferase 4B [ Homo sapiens (human) ]

Gene ID: 64282, updated on 27-Nov-2024

Summary

Official Symbol
TENT4Bprovided by HGNC
Official Full Name
terminal nucleotidyltransferase 4Bprovided by HGNC
Primary source
HGNC:HGNC:30758
See related
Ensembl:ENSG00000121274 MIM:605540; AllianceGenome:HGNC:30758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUT3; PAPD5; TRF4-2
Summary
Enables guanylyltransferase activity; poly(A) RNA polymerase activity; and telomerase RNA binding activity. Involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of mRNA stability. Located in cytosol; nucleolus; and plasma membrane. Part of TRAMP complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 5.4), bone marrow (RPKM 4.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TENT4B in Genome Data Viewer
Location:
16q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (50152911..50235310)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (55950748..56033128)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50186822..50269221)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900375 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:50186273-50187230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7477 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10809 Neighboring gene ribosomal protein L10 pseudogene 14 Neighboring gene MPRA-validated peak2589 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50217888-50218450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50218451-50219012 Neighboring gene Sharpr-MPRA regulatory region 14159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10810 Neighboring gene Sharpr-MPRA regulatory region 8986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278238-50278950 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50278951-50279662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50280376-50281087 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50288095-50288594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50299606-50300199 Neighboring gene adenylate cyclase 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50305212-50306046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:50306047-50306881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:50317845-50318346 Neighboring gene microRNA 6771 Neighboring gene Sharpr-MPRA regulatory region 2137 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:50347343-50348542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:50353005-50354204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10816 Neighboring gene bromodomain containing 7 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ40270

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables guanylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly(A) RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables telomerase RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TRAMP complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
terminal nucleotidyltransferase 4B
Names
PAP associated domain containing 5
PAP-associated domain-containing protein 5
TUTase 3
non-canonical poly(A) RNA polymerase PAPD5
poly(A) RNA polymerase D5, non-canonical
terminal guanylyltransferase
terminal nucleotidyltransferase 4A
terminal uridylyltransferase 3
topoisomerase-related function protein 4-2
NP_001035374.2
NP_001035375.2
NP_001352252.1
NP_001352253.1
XP_011521577.1
XP_011521578.1
XP_011521580.1
XP_047290431.1
XP_047290432.1
XP_047290433.1
XP_054169633.1
XP_054169634.1
XP_054169635.1
XP_054169636.1
XP_054169637.1
XP_054169638.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040284.3NP_001035374.2  terminal nucleotidyltransferase 4B isoform a

    See identical proteins and their annotated locations for NP_001035374.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC007597, AC007610, AK300918
    Consensus CDS
    CCDS54006.1
    UniProtKB/TrEMBL
    G4U4J3, H3BQM0
    Related
    ENSP00000396995.3, ENST00000436909.8
    Conserved Domains (1) summary
    COG5260
    Location:199471
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  2. NM_001040285.3NP_001035375.2  terminal nucleotidyltransferase 4B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC007597, AC007610, AK300918, AL833922
    UniProtKB/Swiss-Prot
    B4DV38, Q8NDF8, Q9NW67, Q9Y6C0
    Conserved Domains (1) summary
    COG5260
    Location:199471
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  3. NM_001365323.2NP_001352252.1  terminal nucleotidyltransferase 4B isoform c

    Status: VALIDATED

    Source sequence(s)
    AC007597, AC007610
    UniProtKB/TrEMBL
    G4U4J3, H3BQM0
    Conserved Domains (1) summary
    COG5260
    Location:194466
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  4. NM_001365324.3NP_001352253.1  terminal nucleotidyltransferase 4B isoform d

    Status: VALIDATED

    Source sequence(s)
    AC007597, AC007610
    Consensus CDS
    CCDS92158.1
    UniProtKB/TrEMBL
    A0A7N4YH79, G4U4J3, H3BQM0
    Related
    ENSP00000455837.3, ENST00000561678.7
    Conserved Domains (1) summary
    COG5260
    Location:214486
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    50152911..50235310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434476.1XP_047290432.1  terminal nucleotidyltransferase 4B isoform X4

  2. XM_011523275.4XP_011521577.1  terminal nucleotidyltransferase 4B isoform X1

    UniProtKB/TrEMBL
    G4U4J3, H3BQM0
    Conserved Domains (1) summary
    COG5260
    Location:200472
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  3. XM_011523276.3XP_011521578.1  terminal nucleotidyltransferase 4B isoform X2

    UniProtKB/Swiss-Prot
    B4DV38, Q8NDF8, Q9NW67, Q9Y6C0
    Conserved Domains (1) summary
    COG5260
    Location:200472
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  4. XM_011523278.3XP_011521580.1  terminal nucleotidyltransferase 4B isoform X5

    See identical proteins and their annotated locations for XP_011521580.1

    UniProtKB/TrEMBL
    Q53F79
    Conserved Domains (1) summary
    COG5260
    Location:27300
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  5. XM_047434477.1XP_047290433.1  terminal nucleotidyltransferase 4B isoform X6

  6. XM_047434475.1XP_047290431.1  terminal nucleotidyltransferase 4B isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    55950748..56033128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313661.1XP_054169636.1  terminal nucleotidyltransferase 4B isoform X4

  2. XM_054313658.1XP_054169633.1  terminal nucleotidyltransferase 4B isoform X1

  3. XM_054313659.1XP_054169634.1  terminal nucleotidyltransferase 4B isoform X2

  4. XM_054313662.1XP_054169637.1  terminal nucleotidyltransferase 4B isoform X5

  5. XM_054313663.1XP_054169638.1  terminal nucleotidyltransferase 4B isoform X6

  6. XM_054313660.1XP_054169635.1  terminal nucleotidyltransferase 4B isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022447.1: Suppressed sequence

    Description
    NM_022447.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.