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TENT4B terminal nucleotidyltransferase 4B [ Homo sapiens (human) ]

Gene ID: 64282, updated on 16-Aug-2021

Summary

Official Symbol
TENT4Bprovided by HGNC
Official Full Name
terminal nucleotidyltransferase 4Bprovided by HGNC
Primary source
HGNC:HGNC:30758
See related
Ensembl:ENSG00000121274 MIM:605540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUT3; PAPD5; TRF4-2
Expression
Ubiquitous expression in testis (RPKM 5.4), bone marrow (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See TENT4B in Genome Data Viewer
Location:
16q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (50152911..50235310)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50186822..50269221)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene HEAT repeat containing 3 Neighboring gene RNY4 pseudogene 3 Neighboring gene ribosomal protein L10 pseudogene 14 Neighboring gene adenylate cyclase 7 Neighboring gene microRNA 6771 Neighboring gene bromodomain containing 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40270

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables guanylyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables polynucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables telomerase RNA binding IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in RNA 3' uridylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in miRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ncRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in sno(s)RNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of TRAMP complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
terminal nucleotidyltransferase 4B
Names
PAP associated domain containing 5
PAP-associated domain-containing protein 5
TUTase 3
non-canonical poly(A) RNA polymerase PAPD5
poly(A) RNA polymerase D5, non-canonical
terminal guanylyltransferase
terminal nucleotidyltransferase 4A
terminal uridylyltransferase 3
topoisomerase-related function protein 4-2
NP_001035374.2
NP_001035375.2
NP_001352252.1
NP_001352253.1
XP_005256150.2
XP_011521577.1
XP_011521578.1
XP_011521580.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040284.3NP_001035374.2  terminal nucleotidyltransferase 4B isoform a

    See identical proteins and their annotated locations for NP_001035374.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC007597, AC007610, AK300918
    Consensus CDS
    CCDS54006.1
    UniProtKB/Swiss-Prot
    Q8NDF8
    Related
    ENSP00000396995.3, ENST00000436909.8
    Conserved Domains (1) summary
    COG5260
    Location:199471
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  2. NM_001040285.3NP_001035375.2  terminal nucleotidyltransferase 4B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC007597, AC007610, AK300918, AL833922
    UniProtKB/Swiss-Prot
    Q8NDF8
    Conserved Domains (1) summary
    COG5260
    Location:199471
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  3. NM_001365323.2NP_001352252.1  terminal nucleotidyltransferase 4B isoform c

    Status: VALIDATED

    Source sequence(s)
    AC007597, AC007610
    Conserved Domains (1) summary
    COG5260
    Location:194466
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  4. NM_001365324.3NP_001352253.1  terminal nucleotidyltransferase 4B isoform d

    Status: VALIDATED

    Source sequence(s)
    AC007597, AC007610
    Related
    ENSP00000455837.3, ENST00000561678.7
    Conserved Domains (1) summary
    COG5260
    Location:214486
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    50152911..50235310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523276.2XP_011521578.1  terminal nucleotidyltransferase 4B isoform X5

    Conserved Domains (1) summary
    COG5260
    Location:200472
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  2. XM_005256093.4XP_005256150.2  terminal nucleotidyltransferase 4B isoform X3

    Conserved Domains (1) summary
    COG5260
    Location:200472
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  3. XM_011523275.3XP_011521577.1  terminal nucleotidyltransferase 4B isoform X1

    Conserved Domains (1) summary
    COG5260
    Location:200472
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
  4. XM_011523278.2XP_011521580.1  terminal nucleotidyltransferase 4B isoform X6

    See identical proteins and their annotated locations for XP_011521580.1

    UniProtKB/TrEMBL
    A0A024R6Q7
    Conserved Domains (1) summary
    COG5260
    Location:27300
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022447.1: Suppressed sequence

    Description
    NM_022447.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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