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Tent4b terminal nucleotidyltransferase 4B [ Mus musculus (house mouse) ]

Gene ID: 214627, updated on 6-Jun-2024

Summary

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Official Symbol
Tent4bprovided by MGI
Official Full Name
terminal nucleotidyltransferase 4Bprovided by MGI
Primary source
MGI:MGI:1917820
See related
Ensembl:ENSMUSG00000036779 AllianceGenome:MGI:1917820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Papd5; 5830428A09; 5730445M16Rik
Summary
Predicted to enable guanylyltransferase activity and polynucleotide adenylyltransferase activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of mRNA stability. Predicted to act upstream of or within cell division; mRNA processing; and rRNA processing. Predicted to be located in cytoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Orthologous to human TENT4B (terminal nucleotidyltransferase 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 23.2), whole brain E14.5 (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tent4b in Genome Data Viewer
Location:
8 C3; 8 43.06 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (88925229..88989942)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88199213..88263314)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1765 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1 Neighboring gene microRNA 7071 Neighboring gene HEAT repeat containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:90808880-90809067 Neighboring gene adenylate cyclase 7 Neighboring gene bromodomain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E6670 Neighboring gene predicted gene, 34751

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAMP complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
terminal nucleotidyltransferase 4B
Names
PAP associated domain containing 5
PAP-associated domain-containing protein 5
TRF4-2
TUTase 3
non-canonical poly(A) RNA polymerase PAPD5
terminal guanylyltransferase
terminal nucleotidyltransferase 4A
terminal uridylyltransferase 3
topoisomerase-related function protein 4-2
NP_001157969.1
NP_001157970.1
NP_001157971.1
NP_001359262.1
NP_001401932.1
NP_001401933.1
XP_006530893.1
XP_006530896.1
XP_017168142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164497.2 → NP_001157969.1  terminal nucleotidyltransferase 4B isoform a

    See identical proteins and their annotated locations for NP_001157969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC126034, AC155170
    Consensus CDS
    CCDS52629.1
    UniProtKB/TrEMBL
    B7ZMU2, E9QJT6
    Related
    ENSMUSP00000112766.2, ENSMUST00000119033.8
    Conserved Domains (1) summary
    COG5260
    Location:181 → 453
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. NM_001164498.2 → NP_001157970.1  terminal nucleotidyltransferase 4B isoform a

    See identical proteins and their annotated locations for NP_001157970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC126034, AC155170
    Consensus CDS
    CCDS52629.1
    UniProtKB/TrEMBL
    B7ZMU2, E9QJT6
    Related
    ENSMUSP00000112608.2, ENSMUST00000118952.8
    Conserved Domains (1) summary
    COG5260
    Location:181 → 453
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  3. NM_001164499.2 → NP_001157971.1  terminal nucleotidyltransferase 4B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC126034, AC155170
    Consensus CDS
    CCDS52630.1
    UniProtKB/TrEMBL
    B7ZMU2, F8WI26
    Related
    ENSMUSP00000067971.4, ENSMUST00000066748.11
    Conserved Domains (1) summary
    COG5260
    Location:181 → 410
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  4. NM_001372333.2 → NP_001359262.1  terminal nucleotidyltransferase 4B isoform c

    Status: VALIDATED

    Source sequence(s)
    AC126034, AC155170
    UniProtKB/TrEMBL
    B7ZMU2
    Related
    ENSMUSP00000160021.1, ENSMUST00000249924.1
    Conserved Domains (1) summary
    COG5260
    Location:201 → 473
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  5. NM_001415003.1 → NP_001401932.1  terminal nucleotidyltransferase 4B isoform d

    Status: VALIDATED

    Source sequence(s)
    AC126034, AC155170
    UniProtKB/TrEMBL
    B7ZMU2
    Related
    ENSMUSP00000120503.3, ENSMUST00000154115.3

  6. NM_001415004.1 → NP_001401933.1  terminal nucleotidyltransferase 4B isoform e

    Status: VALIDATED

    Source sequence(s)
    AC126034, AC155170
    UniProtKB/Swiss-Prot
    A6H635, Q68ED3, Q8C0K6
    UniProtKB/TrEMBL
    B7ZMU2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    88925229..88989942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530830.5 → XP_006530893.1  terminal nucleotidyltransferase 4B isoform X1

    UniProtKB/TrEMBL
    B7ZMU2
    Conserved Domains (1) summary
    COG5260
    Location:201 → 473
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. XM_006530833.5 → XP_006530896.1  terminal nucleotidyltransferase 4B isoform X4

    UniProtKB/TrEMBL
    B7ZMU2
    Conserved Domains (1) summary
    COG5260
    Location:201 → 473
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  3. XM_017312653.2 → XP_017168142.1  terminal nucleotidyltransferase 4B isoform X2

    UniProtKB/TrEMBL
    B7ZMU2
    Conserved Domains (1) summary
    COG5260
    Location:201 → 430
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68ED3.2 GenPept UniProtKB/Swiss-Prot:Q68ED3

Gene LinkOut

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