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TMEM91 transmembrane protein 91 [ Homo sapiens (human) ]

Gene ID: 641649, updated on 13-Mar-2020

Summary

Official Symbol
TMEM91provided by HGNC
Official Full Name
transmembrane protein 91provided by HGNC
Primary source
HGNC:HGNC:32393
See related
Ensembl:ENSG00000142046 MIM:618294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DSPC3; IFITMD6
Expression
Broad expression in bone marrow (RPKM 6.3), testis (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See TMEM91 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41363947..41384083)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41856873..41889988)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97 Neighboring gene transforming growth factor beta 1 Neighboring gene B9 domain containing 2 Neighboring gene exosome component 5 Neighboring gene branched chain keto acid dehydrogenase E1 subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: BCKDHA

Homology

Clone Names

  • FLJ27310, FLJ45695

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 91
Names
dispanin subfamily C member 3
interferon induced transmembrane protein domain containing 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042595.2NP_001036060.1  transmembrane protein 91 isoform b

    See identical proteins and their annotated locations for NP_001036060.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a. Variants 2 and 7 both encode the same isoform (b).
    Source sequence(s)
    AI214374, AI277187, BC063705, BG697182
    Consensus CDS
    CCDS42572.1
    UniProtKB/Swiss-Prot
    Q6ZNR0
    Related
    ENSP00000348750.4, ENST00000356385.8
    Conserved Domains (1) summary
    pfam04505
    Location:92120
    CD225; Interferon-induced transmembrane protein
  2. NM_001098821.2NP_001092291.1  transmembrane protein 91 isoform a

    See identical proteins and their annotated locations for NP_001092291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a).
    Source sequence(s)
    AI214374, AK130820, DA673235
    Consensus CDS
    CCDS42571.1
    UniProtKB/Swiss-Prot
    Q6ZNR0
    Related
    ENSP00000375859.1, ENST00000392002.7
    Conserved Domains (1) summary
    pfam04505
    Location:92157
    CD225; Interferon-induced transmembrane protein
  3. NM_001098822.1NP_001092292.1  transmembrane protein 91 isoform c

    See identical proteins and their annotated locations for NP_001092292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 6, and 8 all encode the same isoform (c).
    Source sequence(s)
    BX090160, DA673235, R67551
    Consensus CDS
    CCDS46082.1
    UniProtKB/Swiss-Prot
    Q6ZNR0
    Related
    ENSP00000437779.1, ENST00000544232.5
    Conserved Domains (1) summary
    pfam04505
    Location:92124
    CD225; Interferon-induced transmembrane protein
  4. NM_001098823.1NP_001092293.1  transmembrane protein 91 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI214374, BF684543, DA673235
    Consensus CDS
    CCDS46083.1
    UniProtKB/Swiss-Prot
    Q6ZNR0
    Related
    ENSP00000405647.2, ENST00000447302.6
    Conserved Domains (1) summary
    pfam04505
    Location:92120
    CD225; Interferon-induced transmembrane protein
  5. NM_001098824.1NP_001092294.1  transmembrane protein 91 isoform e

    See identical proteins and their annotated locations for NP_001092294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform e) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BM675470, BM931402, DA673235
    Consensus CDS
    CCDS46084.1
    UniProtKB/Swiss-Prot
    Q6ZNR0
    Related
    ENSP00000407003.2, ENST00000436170.6
    Conserved Domains (1) summary
    pfam04505
    Location:92120
    CD225; Interferon-induced transmembrane protein
  6. NM_001098825.1NP_001092295.1  transmembrane protein 91 isoform c

    See identical proteins and their annotated locations for NP_001092295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3, 6, and 8 all encode the same isoform (c).
    Source sequence(s)
    AI214374, BM726200, R01772
    Consensus CDS
    CCDS46082.1
    UniProtKB/Swiss-Prot
    Q6ZNR0
    Related
    ENSP00000413192.2, ENST00000413014.6
    Conserved Domains (1) summary
    pfam04505
    Location:92124
    CD225; Interferon-induced transmembrane protein
  7. NM_001369862.1NP_001356791.1  transmembrane protein 91 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC011462
    Conserved Domains (1) summary
    pfam04505
    Location:92120
    CD225; Interferon-induced transmembrane protein
  8. NM_001369864.1NP_001356793.1  transmembrane protein 91 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 3 and 6, encodes isoform c.
    Source sequence(s)
    AC011462
    Conserved Domains (1) summary
    pfam04505
    Location:92124
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41363947..41384083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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