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TINAGL1 tubulointerstitial nephritis antigen like 1 [ Homo sapiens (human) ]

Gene ID: 64129, updated on 5-Aug-2022

Summary

Official Symbol
TINAGL1provided by HGNC
Official Full Name
tubulointerstitial nephritis antigen like 1provided by HGNC
Primary source
HGNC:HGNC:19168
See related
Ensembl:ENSG00000142910 MIM:616064; AllianceGenome:HGNC:19168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARG1; LCN7; LIECG3; TINAGRP
Summary
The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in placenta (RPKM 120.0), fat (RPKM 61.8) and 16 other tissues See more
Orthologs
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Genomic context

See TINAGL1 in Genome Data Viewer
Location:
1p35.2
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31576515..31587686)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31434200..31445387)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32042116..32053287)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1226 Neighboring gene uncharacterized LOC124903917 Neighboring gene Sharpr-MPRA regulatory region 14090 Neighboring gene uncharacterized LOC105378626 Neighboring gene hypocretin receptor 1 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene PEF1 and COL16A1 antisense RNA 1 Neighboring gene collagen type XVI alpha 1 chain

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellular matrix structural constituent NAS
Non-traceable Author Statement
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endosomal transport TAS
Traceable Author Statement
more info
PubMed 
NOT involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulointerstitial nephritis antigen-like
Names
OLRG-2
P3ECSL
TIN Ag-related protein
TIN-Ag-RP
TINAG-like 1
androgen-regulated gene 1
glucocorticoid-inducible protein 5
lipocalin 7
oxidized-LDL responsive gene 2
tubulointerstitial nephritis antigen-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028164.1 RefSeqGene

    Range
    5031..16202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204414.2NP_001191343.1  tubulointerstitial nephritis antigen-like isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF205436, AK298382
    Consensus CDS
    CCDS55586.1
    UniProtKB/Swiss-Prot
    Q9GZM7
    Related
    ENSP00000395137.2, ENST00000457433.6
    Conserved Domains (2) summary
    cd02620
    Location:173424
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:5494
    Somatomedin_B; Somatomedin B domain
  2. NM_001204415.2NP_001191344.1  tubulointerstitial nephritis antigen-like isoform 3

    See identical proteins and their annotated locations for NP_001191344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF205436, AK298382, BM923842
    Consensus CDS
    CCDS72745.1
    UniProtKB/Swiss-Prot
    Q9GZM7
    UniProtKB/TrEMBL
    F6SDV2
    Related
    ENSP00000445392.2, ENST00000537531.2
    Conserved Domains (2) summary
    cd02620
    Location:99350
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam05375
    Location:1236
    Pacifastin_I; Pacifastin inhibitor (LCMII)
  3. NM_022164.3NP_071447.1  tubulointerstitial nephritis antigen-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_071447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC064633, DA656570
    Consensus CDS
    CCDS343.1
    UniProtKB/Swiss-Prot
    Q96JW3, Q9GZM7
    Related
    ENSP00000271064.7, ENST00000271064.12
    Conserved Domains (3) summary
    cd02620
    Location:204455
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    cl17735
    Location:105140
    VWC; von Willebrand factor type C domain
    cl02508
    Location:5494
    Somatomedin_B; Somatomedin B domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    31576515..31587686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271106.4XP_005271163.1  tubulointerstitial nephritis antigen-like isoform X1

    Conserved Domains (1) summary
    cl23744
    Location:204364
    Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
  2. XM_005271107.2XP_005271164.1  tubulointerstitial nephritis antigen-like isoform X3

    See identical proteins and their annotated locations for XP_005271164.1

    UniProtKB/TrEMBL
    F6SDV2
    Conserved Domains (2) summary
    cd02620
    Location:99350
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam05375
    Location:1236
    Pacifastin_I; Pacifastin inhibitor (LCMII)
  3. XM_047427608.1XP_047283564.1  tubulointerstitial nephritis antigen-like isoform X4

  4. XM_011541946.2XP_011540248.2  tubulointerstitial nephritis antigen-like isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    31434200..31445387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)