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TINAGL1 tubulointerstitial nephritis antigen like 1 [ Homo sapiens (human) ]

Gene ID: 64129, updated on 12-Oct-2019

Summary

Official Symbol
TINAGL1provided by HGNC
Official Full Name
tubulointerstitial nephritis antigen like 1provided by HGNC
Primary source
HGNC:HGNC:19168
See related
Ensembl:ENSG00000142910 MIM:616064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARG1; LCN7; LIECG3; TINAGRP
Summary
The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in placenta (RPKM 120.0), fat (RPKM 61.8) and 16 other tissues See more
Orthologs

Genomic context

See TINAGL1 in Genome Data Viewer
Location:
1p35.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (31576384..31587686)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32042086..32053290)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine decarboxylase 1, pseudogene Neighboring gene long intergenic non-protein coding RNA 1226 Neighboring gene uncharacterized LOC105378626 Neighboring gene hypocretin receptor 1 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene uncharacterized LOC105378628 Neighboring gene PEF1 and COL16A1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix structural constituent NAS
Non-traceable Author Statement
more info
PubMed 
extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
laminin binding IEA
Inferred from Electronic Annotation
more info
 
polysaccharide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
endosomal transport TAS
Traceable Author Statement
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
NOT proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
tubulointerstitial nephritis antigen-like
Names
OLRG-2
P3ECSL
TIN Ag-related protein
TIN-Ag-RP
TINAG-like 1
androgen-regulated gene 1
glucocorticoid-inducible protein 5
lipocalin 7
oxidized-LDL responsive gene 2
tubulointerstitial nephritis antigen-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028164.1 RefSeqGene

    Range
    5031..16202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204414.1NP_001191343.1  tubulointerstitial nephritis antigen-like isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF205436, AK298382, DA656570
    Consensus CDS
    CCDS55586.1
    UniProtKB/Swiss-Prot
    Q9GZM7
    Related
    ENSP00000395137.2, ENST00000457433.6
    Conserved Domains (2) summary
    cd02620
    Location:173424
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:5494
    Somatomedin_B; Somatomedin B domain
  2. NM_001204415.1NP_001191344.1  tubulointerstitial nephritis antigen-like isoform 3

    See identical proteins and their annotated locations for NP_001191344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF205436, AK298382, BM923842
    Consensus CDS
    CCDS72745.1
    UniProtKB/Swiss-Prot
    Q9GZM7
    UniProtKB/TrEMBL
    F6SDV2
    Related
    ENSP00000445392.2, ENST00000537531.2
    Conserved Domains (2) summary
    cd02620
    Location:99350
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    cl17735
    Location:446
    VWC; von Willebrand factor type C domain
  3. NM_022164.3NP_071447.1  tubulointerstitial nephritis antigen-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_071447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC064633, DA656570
    Consensus CDS
    CCDS343.1
    UniProtKB/Swiss-Prot
    Q9GZM7
    Related
    ENSP00000271064.7, ENST00000271064.12
    Conserved Domains (1) summary
    cd02620
    Location:204455
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    31576384..31587686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541946.1XP_011540248.1  tubulointerstitial nephritis antigen-like isoform X2

    Conserved Domains (1) summary
    cd02620
    Location:145396
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
  2. XM_005271106.3XP_005271163.1  tubulointerstitial nephritis antigen-like isoform X1

    Conserved Domains (2) summary
    cl02508
    Location:5494
    Somatomedin_B; Somatomedin B domain
    cl23744
    Location:204364
    Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
  3. XM_005271107.2XP_005271164.1  tubulointerstitial nephritis antigen-like isoform X3

    See identical proteins and their annotated locations for XP_005271164.1

    UniProtKB/TrEMBL
    F6SDV2
    Conserved Domains (2) summary
    cd02620
    Location:99350
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    cl17735
    Location:446
    VWC; von Willebrand factor type C domain
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