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Tinagl1 tubulointerstitial nephritis antigen-like 1 [ Mus musculus (house mouse) ]

Gene ID: 94242, updated on 26-Sep-2022

Summary

Official Symbol
Tinagl1provided by MGI
Official Full Name
tubulointerstitial nephritis antigen-like 1provided by MGI
Primary source
MGI:MGI:2137617
See related
Ensembl:ENSMUSG00000028776 AllianceGenome:MGI:2137617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AZ1; AZ-1; Arg1; Lcn7; TARP; Tinagl; 1110021J17Rik
Summary
Enables laminin binding activity. Predicted to be involved in proteolysis. Located in cytoplasm. Is expressed in several structures, including adrenal gland; blastocyst; brain ventricle; early embryo; and submandibular gland primordium. Orthologous to human TINAGL1 (tubulointerstitial nephritis antigen like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 158.0), placenta adult (RPKM 140.0) and 19 other tissues See more
Orthologs
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Genomic context

See Tinagl1 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (130059393..130068915, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (130165600..130175122, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hypocretin (orexin) receptor 1 Neighboring gene predicted gene, 40259 Neighboring gene predicted gene, 52490 Neighboring gene leucine decarboxylase 1 Neighboring gene predicted gene, 46724

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables laminin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tubulointerstitial nephritis antigen-like
Names
adrenocortical zonation factor 1
androgen-regulated gene 1 protein
tubulointerstitial nephritis antigen-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168333.1NP_001161805.1  tubulointerstitial nephritis antigen-like precursor

    See identical proteins and their annotated locations for NP_001161805.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB050626, AL606925
    Consensus CDS
    CCDS18708.2
    UniProtKB/Swiss-Prot
    Q99JR5, Q9EQT9
    Related
    ENSMUSP00000101621.3, ENSMUST00000105999.9
    Conserved Domains (3) summary
    cd02620
    Location:203454
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:5393
    Somatomedin_B; Somatomedin B domain
    cl17735
    Location:104152
    VWC; von Willebrand factor type C domain
  2. NM_023476.3NP_075965.2  tubulointerstitial nephritis antigen-like precursor

    See identical proteins and their annotated locations for NP_075965.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL606925
    Consensus CDS
    CCDS18708.2
    UniProtKB/Swiss-Prot
    Q99JR5, Q9EQT9
    Related
    ENSMUSP00000101620.2, ENSMUST00000105998.8
    Conserved Domains (3) summary
    cd02620
    Location:203454
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam01033
    Location:5393
    Somatomedin_B; Somatomedin B domain
    cl17735
    Location:104152
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    130059393..130068915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)