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VSIR V-set immunoregulatory receptor [ Homo sapiens (human) ]

Gene ID: 64115, updated on 7-Jun-2020

Summary

Official Symbol
VSIRprovided by HGNC
Official Full Name
V-set immunoregulatory receptorprovided by HGNC
Primary source
HGNC:HGNC:30085
See related
Ensembl:ENSG00000107738 MIM:615608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha
Expression
Broad expression in spleen (RPKM 39.2), bone marrow (RPKM 38.8) and 23 other tissues See more
Orthologs

Genomic context

See VSIR in Genome Data Viewer
Location:
10q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (71747556..71773520, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73507313..73533337, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cadherin related 23 Neighboring gene uncharacterized LOC105378355 Neighboring gene chromosome 10 open reading frame 105 Neighboring gene Sharpr-MPRA regulatory region 2121 Neighboring gene microRNA 7152

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
NHGRI GWA Catalog
Genome-wide association study of smoking behaviours in patients with COPD.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
V-type immunoglobulin domain-containing suppressor of T-cell activation
Names
Death Domain1alpha
PDCD1 homolog
V-domain Ig suppressor of T cell activation
V-set domain-containing immunoregulatory receptor
platelet receptor GI24
sisp-1
stress-induced secreted protein-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022153.2NP_071436.1  V-type immunoglobulin domain-containing suppressor of T-cell activation precursor

    See identical proteins and their annotated locations for NP_071436.1

    Status: VALIDATED

    Source sequence(s)
    AL731541, AY358379
    Consensus CDS
    CCDS31218.1
    UniProtKB/Swiss-Prot
    Q9H7M9
    Related
    ENSP00000378409.3, ENST00000394957.8
    Conserved Domains (1) summary
    cl11960
    Location:45149
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    71747556..71773520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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