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VSIR V-set immunoregulatory receptor [ Homo sapiens (human) ]

Gene ID: 64115, updated on 5-Aug-2022

Summary

Official Symbol
VSIRprovided by HGNC
Official Full Name
V-set immunoregulatory receptorprovided by HGNC
Primary source
HGNC:HGNC:30085
See related
Ensembl:ENSG00000107738 MIM:615608; AllianceGenome:HGNC:30085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha
Summary
Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 39.2), bone marrow (RPKM 38.8) and 23 other tissues See more
Orthologs
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Genomic context

See VSIR in Genome Data Viewer
Location:
10q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (71747556..71773520, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (72618370..72644252, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73507313..73533277, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cadherin related 23 Neighboring gene Sharpr-MPRA regulatory region 11817 Neighboring gene chromosome 10 open reading frame 105 Neighboring gene Sharpr-MPRA regulatory region 2121 Neighboring gene microRNA 7152

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of lung function decline in adults with and without asthma.
EBI GWAS Catalog
Genome-wide association study of smoking behaviours in patients with COPD.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of CD8-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of alpha-beta T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-17 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in zymogen activation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
V-type immunoglobulin domain-containing suppressor of T-cell activation
Names
Death Domain1alpha
PDCD1 homolog
V-domain Ig suppressor of T cell activation
V-set domain-containing immunoregulatory receptor
platelet receptor GI24
sisp-1
stress-induced secreted protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022153.2NP_071436.1  V-type immunoglobulin domain-containing suppressor of T-cell activation precursor

    See identical proteins and their annotated locations for NP_071436.1

    Status: VALIDATED

    Source sequence(s)
    AL731541, AY358379
    Consensus CDS
    CCDS31218.1
    UniProtKB/Swiss-Prot
    Q8WYZ8, Q9H7M9
    Related
    ENSP00000378409.3, ENST00000394957.8
    Conserved Domains (1) summary
    cl11960
    Location:45149
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    71747556..71773520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    72618370..72644252 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)