Vsir V-set immunoregulatory receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vsirprovided by MGI
Official Full Name: V-set immunoregulatory receptorprovided by MGI
Primary source: MGI:MGI:1921298
See related: Ensembl:ENSMUSG00000020101 AllianceGenome:MGI:1921298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dies1; PD-1H; VISTA; 4632428N05Rik
Summary: Predicted to enable endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of T cell cytokine production; and positive regulation of BMP signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including heart; immune system; lung; male reproductive gland or organ; and small intestine lamina propria. Orthologous to human VSIR (V-set immunoregulatory receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 21.5), mammary gland adult (RPKM 18.6) and 21 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10; 10 B4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (60182630..60266073)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (60346851..60430294)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VISTA as a ligand downregulates LPS-mediated inflammation in macrophages and neutrophils.
Title: VISTA as a ligand downregulates LPS-mediated inflammation in macrophages and neutrophils.
Kidney VISTA prevents IFN-gamma/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury.
Title: Kidney VISTA prevents IFN-γ/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury.
VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology.
Title: VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology.
VISTA deficiency protects from immune complex-mediated glomerulonephritis by inhibiting neutrophil activation.
Title: VISTA deficiency protects from immune complex-mediated glomerulonephritis by inhibiting neutrophil activation.
Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir(-/-) murine psoriasis.
Title: Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir(-/-) murine psoriasis.
Defining the Signature of VISTA on Myeloid Cell Chemokine Responsiveness.
Title: Defining the Signature of VISTA on Myeloid Cell Chemokine Responsiveness.
PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.
Title: PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.
VISTA is therefore a distinctive negative checkpoint regulator of naive T cells that is critical for steady-state maintenance of quiescence and peripheral tolerance.
Title: VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.
VISTA may play an essential role in the acceptance of corneal allografts via involvement with allospecific ACAID, which suppresses T cell infiltration into the cornea.
Title: VISTA Is Crucial for Corneal Allograft Survival and Maintenance of Immune Privilege.
findings identify a mechanism by which VISTA may engender resistance to anti-tumour immune responses, as well as an unexpectedly determinative role for pH in immune co-receptor engagement
Title: VISTA is an acidic pH-selective ligand for PSGL-1.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (6)

General gene information

Go to the top of the page Help

Homology

Homologs of the Vsir gene: The Vsir gene is conserved in human, chimpanzee, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 484 organisms have orthologs with human gene Vsir
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD8-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of alpha-beta T cell activation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: V-type immunoglobulin domain-containing suppressor of T-cell activation

Names: V-set domain-containing immunoregulatory receptor; differentiation of ESCs 1; platelet receptor Gi24

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159572.1 → NP_001153044.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AK131118, BY202363

Consensus CDS

CCDS48569.1

UniProtKB/Swiss-Prot

Q6KAT9, Q9D659

Related

ENSMUSP00000101100.2, ENSMUST00000105460.8

Conserved Domains (1) summary

cd20980
Location:34 → 180

IgV_VISTA; Immunoglobulin variable (IgV) domain of V-domain immunoglobulin suppressor of T cell activation (VISTA)
NM_028732.4 → NP_083008.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 1 precursor

See identical proteins and their annotated locations for NP_083008.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK014600, AK142494, BY202363

Consensus CDS

CCDS35912.1

UniProtKB/Swiss-Prot

Q9D659

UniProtKB/TrEMBL

A0A171EBK7

Related

ENSMUSP00000020301.8, ENSMUST00000020301.14

Conserved Domains (2) summary

smart00410
Location:38 → 147

IG_like; Immunoglobulin like

cl11960
Location:45 → 167

Ig; Immunoglobulin domain