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CRLF2 cytokine receptor like factor 2 [ Homo sapiens (human) ]

Gene ID: 64109, updated on 12-Aug-2018

Summary

Official Symbol
CRLF2provided by HGNC
Official Full Name
cytokine receptor like factor 2provided by HGNC
Primary source
HGNC:HGNC:14281
See related
Ensembl:ENSG00000205755 MIM:300357; MIM:400023; Vega:OTTHUMG00000067432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRL2; TSLPR; CRLF2Y
Summary
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CRLF2 in Genome Data Viewer
Location:
Xp22.33 and Yp11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (1190437..1212762, complement)
109 current GRCh38.p12 (GCF_000001405.38) Y NC_000024.10 (1190437..1212762, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1314869..1331529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1264869..1281529, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene repetin pseudogene Neighboring gene 60S ribosomal protein L6-like Neighboring gene uncharacterized LOC107985697 Neighboring gene colony stimulating factor 2 receptor alpha subunit Neighboring gene uncharacterized LOC112268304

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene repetin pseudogene Neighboring gene 60S ribosomal protein L6-like Neighboring gene uncharacterized LOC107985697 Neighboring gene colony stimulating factor 2 receptor alpha subunit Neighboring gene uncharacterized LOC112268304

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of cytokine receptor-like factor 2 (CRLF2) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem
    Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytokine receptor-like factor 2
Names
IL-XR
TSLP receptor
cytokine receptor CRL2 precusor
thymic stromal lymphopoietin protein receptor
thymic stromal-derived lymphopoietin receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034237.1 RefSeqGene

    Range
    5001..27228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012288.2NP_001012288.2  cytokine receptor-like factor 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon which results in translation initiation at a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF142570, AK026800, AY775789
    Consensus CDS
    CCDS75944.1
    UniProtKB/Swiss-Prot
    Q9HC73
    Related
    ENSP00000370979.4, ENST00000381567.8
    Conserved Domains (1) summary
    cd00063
    Location:776
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_022148.3NP_071431.2  cytokine receptor-like factor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_071431.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF142570, AK026800
    Consensus CDS
    CCDS75945.1
    UniProtKB/Swiss-Prot
    Q9HC73
    UniProtKB/TrEMBL
    D0E2W4
    Related
    ENSP00000383641.3, OTTHUMP00000070430, ENST00000400841.7, OTTHUMT00000144413
    Conserved Domains (1) summary
    cd00063
    Location:119207
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_110830.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon, lacks an alternate exon, and contains another alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF142570, AK026800
    Related
    ENST00000467626.6, OTTHUMT00000144414

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    1190437..1212762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546181.2XP_011544483.1  cytokine receptor-like factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011544483.1

    Conserved Domains (1) summary
    cd00063
    Location:118206
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011546182.2XP_011544484.1  cytokine receptor-like factor 2 isoform X2

    See identical proteins and their annotated locations for XP_011544484.1

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p12 Primary Assembly

    Range
    1190437..1212762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545634.2XP_011543936.1  cytokine receptor-like factor 2 isoform X1

    See identical proteins and their annotated locations for XP_011543936.1

    Conserved Domains (1) summary
    cd00063
    Location:118206
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_011545635.2XP_011543937.1  cytokine receptor-like factor 2 isoform X2

    See identical proteins and their annotated locations for XP_011543937.1

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