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SELP selectin P [ Homo sapiens (human) ]

Gene ID: 6403, updated on 22-Nov-2020

Summary

Official Symbol
SELPprovided by HGNC
Official Full Name
selectin Pprovided by HGNC
Primary source
HGNC:HGNC:10721
See related
Ensembl:ENSG00000174175 MIM:173610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
Summary
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Expression
Broad expression in urinary bladder (RPKM 9.3), appendix (RPKM 7.3) and 20 other tissues See more
Orthologs

Genomic context

See SELP in Genome Data Viewer
Location:
1q24.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (169588849..169630125, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169558087..169599377, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 19 member 2 Neighboring gene coagulation factor V Neighboring gene Sharpr-MPRA regulatory region 2803 Neighboring gene uncharacterized LOC107985745 Neighboring gene selectin L

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
GeneReviews: Not available
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
GeneReviews: Not available
Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.
GeneReviews: Not available
Multiple loci influencing hippocampal degeneration identified by genome scan.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
fucose binding IDA
Inferred from Direct Assay
more info
PubMed 
glycosphingolipid binding TAS
Traceable Author Statement
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sialic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
platelet dense granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P-selectin
Names
CD62 antigen-like family member P
GMP-140
granule membrane protein 140
granule membrane protein 140kDa
granulocyte membrane protein
leukocyte-endothelial cell adhesion molecule 3
platelet activation dependent granule-external membrane protein
platelet alpha-granule membrane protein
selectin P (granule membrane protein 140kDa, antigen CD62)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012125.2 RefSeqGene

    Range
    5016..46291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003005.4NP_002996.2  P-selectin precursor

    See identical proteins and their annotated locations for NP_002996.2

    Status: REVIEWED

    Source sequence(s)
    BC068533, DA926598, DA994564, M25322
    Consensus CDS
    CCDS1282.1
    UniProtKB/Swiss-Prot
    P16109
    UniProtKB/TrEMBL
    A0A024R8Y9, Q6NUL9
    Related
    ENSP00000263686.5, ENST00000263686.11
    Conserved Domains (4) summary
    cd00033
    Location:572630
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:505761
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    169588849..169630125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245440.2XP_005245497.1  P-selectin isoform X3

    See identical proteins and their annotated locations for XP_005245497.1

    UniProtKB/TrEMBL
    Q5R341
    Related
    ENSP00000356760.1, ENST00000367786.6
    Conserved Domains (4) summary
    cd00033
    Location:510568
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:443699
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  2. XM_005245439.2XP_005245496.1  P-selectin isoform X2

    See identical proteins and their annotated locations for XP_005245496.1

    Conserved Domains (4) summary
    cd00033
    Location:572630
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:505761
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  3. XM_005245438.2XP_005245495.1  P-selectin isoform X2

    See identical proteins and their annotated locations for XP_005245495.1

    Related
    ENSP00000391694.2, ENST00000426706.6
    Conserved Domains (4) summary
    cd00033
    Location:572630
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:505761
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  4. XM_005245435.2XP_005245492.1  P-selectin isoform X1

    See identical proteins and their annotated locations for XP_005245492.1

    UniProtKB/Swiss-Prot
    P16109
    UniProtKB/TrEMBL
    A0A024R8Y9
    Conserved Domains (4) summary
    cd00033
    Location:572630
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:505761
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
  5. XM_005245436.4XP_005245493.1  P-selectin isoform X1

    See identical proteins and their annotated locations for XP_005245493.1

    UniProtKB/Swiss-Prot
    P16109
    UniProtKB/TrEMBL
    A0A024R8Y9
    Related
    ENSP00000356762.1, ENST00000367788.6
    Conserved Domains (4) summary
    cd00033
    Location:572630
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    PHA02927
    Location:505761
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
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