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SELE selectin E [ Homo sapiens (human) ]

Gene ID: 6401, updated on 5-Jan-2022

Summary

Official Symbol
SELEprovided by HGNC
Official Full Name
selectin Eprovided by HGNC
Primary source
HGNC:HGNC:10718
See related
Ensembl:ENSG00000007908 MIM:131210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELAM; ESEL; CD62E; ELAM1; LECAM2
Summary
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 16.5), urinary bladder (RPKM 15.5) and 12 other tissues See more
Orthologs
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Genomic context

See SELE in Genome Data Viewer
Location:
1q24.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (169722640..169734079, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169691781..169703220, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985745 Neighboring gene selectin L Neighboring gene uncharacterized LOC101928628 Neighboring gene chromosome 1 open reading frame 112 Neighboring gene methyltransferase like 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin PubMed
tat HIV-1 Tat upregulates E-selectin (ELAM-1) in endothelial cells via an NF-kappa B-dependent mechanism PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oligosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament-based process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration involved in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of leukocyte tethering or rolling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide TAS
Traceable Author Statement
more info
PubMed 
involved_in response to tumor necrosis factor TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
E-selectin
Names
CD62 antigen-like family member E
ELAM-1
endothelial adhesion molecule 1
endothelial leukocyte adhesion molecule 1
leukocyte endothelial cell adhesion molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012124.1 RefSeqGene

    Range
    5001..16440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000450.2NP_000441.2  E-selectin precursor

    See identical proteins and their annotated locations for NP_000441.2

    Status: REVIEWED

    Source sequence(s)
    BC142711, DB209354
    Consensus CDS
    CCDS1283.1
    UniProtKB/Swiss-Prot
    P16581
    Related
    ENSP00000331736.7, ENST00000333360.12
    Conserved Domains (3) summary
    cd03592
    Location:22140
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:148175
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl27761
    Location:333547
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    169722640..169734079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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