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CIDEC cell death inducing DFFA like effector c [ Homo sapiens (human) ]

Gene ID: 63924, updated on 7-Jun-2020

Summary

Official Symbol
CIDECprovided by HGNC
Official Full Name
cell death inducing DFFA like effector cprovided by HGNC
Primary source
HGNC:HGNC:24229
See related
Ensembl:ENSG00000187288 MIM:612120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIDE3; FPLD5; FSP27; CIDE-3
Summary
This gene encodes a member of the cell death-inducing DNA fragmentation factor-like effector family. Members of this family play important roles in apoptosis. The encoded protein promotes lipid droplet formation in adipocytes and may mediate adipocyte apoptosis. This gene is regulated by insulin and its expression is positively correlated with insulin sensitivity. Mutations in this gene may contribute to insulin resistant diabetes. A pseudogene of this gene is located on the short arm of chromosome 3. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Biased expression in fat (RPKM 484.8), small intestine (RPKM 36.2) and 1 other tissue See more
Orthologs

Genomic context

See CIDEC in Genome Data Viewer
Location:
3p25.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9866710..9880254, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9908394..9921938, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14744 Neighboring gene jagunal homolog 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20871

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid droplet organization TAS
Traceable Author Statement
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell death activator CIDE-3
Names
fat specific protein 27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042291.1 RefSeqGene

    Range
    5002..18541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199551.1NP_001186480.1  cell death activator CIDE-3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and contains an alternate coding exon, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC018809, AL598731, BC016851, CD518729
    Consensus CDS
    CCDS56239.1
    UniProtKB/Swiss-Prot
    Q96AQ7
    Related
    ENSP00000483641.1, ENST00000618572.4
    Conserved Domains (1) summary
    cl02541
    Location:41130
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
  2. NM_001199552.2NP_001186481.1  cell death activator CIDE-3 isoform 3

    See identical proteins and their annotated locations for NP_001186481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC018809, AL598731, BC016851, CD519587
    Consensus CDS
    CCDS2587.1
    UniProtKB/Swiss-Prot
    Q96AQ7
    UniProtKB/TrEMBL
    A0A024R2F7
    Conserved Domains (1) summary
    cl02541
    Location:41120
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
  3. NM_001199623.1NP_001186552.1  cell death activator CIDE-3 isoform 1

    See identical proteins and their annotated locations for NP_001186552.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC018809, AL598630, BC016851
    Consensus CDS
    CCDS74897.1
    UniProtKB/Swiss-Prot
    Q96AQ7
    UniProtKB/TrEMBL
    A0A0A0MRY9
    Related
    ENSP00000373328.2, ENST00000383817.5
    Conserved Domains (1) summary
    cl02541
    Location:54133
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
  4. NM_001321142.2NP_001308071.1  cell death activator CIDE-3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AF303893, AI460316, AK024524, AL598731, BC016851, BQ695178, CD518776
    Consensus CDS
    CCDS2587.1
    UniProtKB/Swiss-Prot
    Q96AQ7
    UniProtKB/TrEMBL
    A0A024R2F7
    Conserved Domains (1) summary
    cl02541
    Location:41120
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
  5. NM_001321143.2NP_001308072.1  cell death activator CIDE-3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AI460316, AK024524, AL598731, AY364640, BC016851
    Consensus CDS
    CCDS82731.1
    UniProtKB/Swiss-Prot
    Q96AQ7
    Related
    ENSP00000392975.1, ENST00000455015.5
    Conserved Domains (1) summary
    cl02541
    Location:146
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
  6. NM_001321144.2NP_001308073.1  cell death activator CIDE-3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AF303893, AI460316, AK024524, AL598731, BC016851
    Consensus CDS
    CCDS82731.1
    UniProtKB/Swiss-Prot
    Q96AQ7
    Related
    ENSP00000400649.1, ENST00000423850.5
    Conserved Domains (1) summary
    cl02541
    Location:146
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
  7. NM_001378491.1NP_001365420.1  cell death activator CIDE-3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018809
  8. NM_022094.3NP_071377.2  cell death activator CIDE-3 isoform 3

    See identical proteins and their annotated locations for NP_071377.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC018809, AF303893, BC016851
    Consensus CDS
    CCDS2587.1
    UniProtKB/Swiss-Prot
    Q96AQ7
    UniProtKB/TrEMBL
    A0A024R2F7
    Related
    ENSP00000338642.2, ENST00000336832.6
    Conserved Domains (1) summary
    cl02541
    Location:41120
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9866710..9880254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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