CXCL6 C-X-C motif chemokine ligand 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CXCL6provided by HGNC
Official Full Name: C-X-C motif chemokine ligand 6provided by HGNC
Primary source: HGNC:HGNC:10643
See related: Ensembl:ENSG00000124875 MIM:138965; AllianceGenome:HGNC:10643
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GCP2; CKA-3; GCP-2; SCYB6
Summary: The protein encoded by this gene is a member CXC chemokine family. The encoded protein is a chemotactic for neutrophil granulocytes and has antibacterial action against gram-negative and gram-positive bacteria. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Jun 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Biased expression in spleen (RPKM 44.2), gall bladder (RPKM 20.7) and 4 other tissues See more
Orthologs: all
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Genomic context

Location:: 4q13.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (73836678..73838760)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (77180324..77182406)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (74702395..74704477)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCL6: A potential therapeutic target for inflammation and cancer.
Title: CXCL6: A potential therapeutic target for inflammation and cancer.
circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6.
Title: circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6.
CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation.
Title: CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation.
CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway.
Title: CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway.
Hypoxia-CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia.
Title: Hypoxia-CXCL6 axis affects arteriolar niche remodeling in acute myeloid leukemia.
Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6.
Title: Potential Repressive Impact of microRNA-20a on Renal Tubular Damage in Diabetic Kidney Disease by Targeting C-X-C Motif Chemokine Ligand 6.
Diagnostic value of GCP-2/CXCL-6 and hs-CRP in the diagnosis of acute appendicitis.", trans "Akut apandisit tanisinda GCP-2/CXCL-6 ve hs-CRP'nin tanisal degeri.
Title: Diagnostic value of GCP-2/CXCL-6 and hs-CRP in the diagnosis of acute appendicitis.
High CXCL6 expression in the wound exudate is associated with rapid wound healing of diabetic foot ulcers.
Title: Wound exudate CXCL6: a potential biomarker for wound healing of diabetic foot ulcers.
our results reveal that CXCL6 plays an important role in liver fibrosis through stimulating the release of TGF-beta by Kupffer cells and thereby activating hepatic stellate cell.
Title: CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis.
The results suggest a notable angiogenic potential of cardiac progenitor cells and identify CXCL6 as an important paracrine factor for cardiac progenitor cells that signals mainly through CXCR2.
Title: CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-X-C motif) ligand 6 (CXCL6) in peptide-treated PBMCs	PubMed
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of chemokine (C-X-C motif) ligand 6 (CXCL6) in primary human brain microvascular endothelial cells	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC201041P2 (e-PCR)
- UniSTS:271878

RH70711 (e-PCR)
- UniSTS:71621

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte homeostasis	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of chemokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neutrophil mediated killing of gram-negative bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 6

Names: chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); chemokine alpha 3; granulocyte chemotactic protein 2; small inducible cytokine subfamily B (Cys-X-Cys), member 6 (granulocyte chemotactic protein 2); small inducible cytokine subfamily B (Cys-X-Cys), member b; small-inducible cytokine B6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002993.4 → NP_002984.1 C-X-C motif chemokine 6 precursor

See identical proteins and their annotated locations for NP_002984.1

Status: REVIEWED

Source sequence(s)

AC108029, BP204144, U81234

Consensus CDS

CCDS3560.1

UniProtKB/Swiss-Prot

B2R4X3, P80162, Q4W5D4

UniProtKB/TrEMBL

D6RF92

Related

ENSP00000226317.5, ENST00000226317.10

Conserved Domains (1) summary

cd00273
Location:46 → 107

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...