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CCL25 C-C motif chemokine ligand 25 [ Homo sapiens (human) ]

Gene ID: 6370, updated on 1-Jun-2020

Summary

Official Symbol
CCL25provided by HGNC
Official Full Name
C-C motif chemokine ligand 25provided by HGNC
Primary source
HGNC:HGNC:10624
See related
Ensembl:ENSG00000131142 MIM:602565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TECK; Ckb15; SCYA25
Summary
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Restricted expression toward small intestine (RPKM 203.4) See more
Orthologs

Genomic context

See CCL25 in Genome Data Viewer
Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8052318..8062663)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8117224..8127547)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ELAV like RNA binding protein 1 Neighboring gene uncharacterized LOC105372266 Neighboring gene fibrillin 3 Neighboring gene ALG11, alpha-1,2-mannosyltransferase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150327

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CCR10 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-C motif chemokine 25
Names
Ck beta-15
TECKvar
chemokine (C-C motif) ligand 25
chemokine TECK
small inducible cytokine subfamily A (Cys-Cys), member 25
small-inducible cytokine A25
thymus expressed chemokine

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201359.1NP_001188288.1  C-C motif chemokine 25 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001188288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC008946, AI313430, AK292662
    Consensus CDS
    CCDS56080.1
    UniProtKB/Swiss-Prot
    O15444
    Related
    ENSP00000253451.4, ENST00000253451.8
    Conserved Domains (1) summary
    cd01119
    Location:2891
    Chemokine_CC_DCCL; Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic ...
  2. NM_005624.3NP_005615.2  C-C motif chemokine 25 isoform 1 precursor

    See identical proteins and their annotated locations for NP_005615.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC008946, AI313430, BC130561
    Consensus CDS
    CCDS12194.1
    UniProtKB/Swiss-Prot
    O15444
    Related
    ENSP00000375086.3, ENST00000390669.7
    Conserved Domains (1) summary
    cd01119
    Location:2891
    Chemokine_CC_DCCL; Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    8052318..8062663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528177.2XP_011526479.1  C-C motif chemokine 25 isoform X2

    See identical proteins and their annotated locations for XP_011526479.1

    UniProtKB/Swiss-Prot
    O15444
    Conserved Domains (1) summary
    cd01119
    Location:2891
    Chemokine_CC_DCCL; Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic ...
  2. XM_017027121.1XP_016882610.1  C-C motif chemokine 25 isoform X2

    UniProtKB/Swiss-Prot
    O15444
    Conserved Domains (1) summary
    cd01119
    Location:2891
    Chemokine_CC_DCCL; Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic ...
  3. XM_017027122.1XP_016882611.1  C-C motif chemokine 25 isoform X3

    UniProtKB/Swiss-Prot
    O15444
    Conserved Domains (1) summary
    cd01119
    Location:2891
    Chemokine_CC_DCCL; Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic ...
  4. XM_017027119.1XP_016882608.1  C-C motif chemokine 25 isoform X1

  5. XM_017027120.1XP_016882609.1  C-C motif chemokine 25 isoform X2

    UniProtKB/Swiss-Prot
    O15444
    Conserved Domains (1) summary
    cd01119
    Location:2891
    Chemokine_CC_DCCL; Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_148888.1: Suppressed sequence

    Description
    NM_148888.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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