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Ccl25 chemokine (C-C motif) ligand 25 [ Mus musculus (house mouse) ]

Gene ID: 20300, updated on 8-Dec-2022

Summary

Official Symbol
Ccl25provided by MGI
Official Full Name
chemokine (C-C motif) ligand 25provided by MGI
Primary source
MGI:MGI:1099448
See related
Ensembl:ENSMUSG00000023235 AllianceGenome:MGI:1099448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TECK; CKb15; Scya25; A130072A22Rik
Summary
Enables chemokine activity. Acts upstream of or within chemotaxis and leukocyte migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in 3rd branchial pouch; central nervous system; hemolymphoid system; retina; and thymus/parathyroid primordium. Orthologous to human CCL25 (C-C motif chemokine ligand 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 91.4), thymus adult (RPKM 40.0) and 2 other tissues See more
Orthologs
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Genomic context

See Ccl25 in Genome Data Viewer
Location:
8 A1.1; 8 2.01 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4375207..4410020)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4325205..4360020)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) Neighboring gene predicted gene, 50600 Neighboring gene predicted gene 7434 Neighboring gene peptidylprolyl isomerase A pseudogene 8_36.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR10 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity ISO
Inferred from Sequence Orthology
more info
 
enables chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in killing of cells of another organism ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lymphoid lineage cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
C-C motif chemokine 25
Names
small inducible chemokine 25
small inducible cytokine A25
thymus-expressed chemokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009138.3NP_033164.1  C-C motif chemokine 25 precursor

    See identical proteins and their annotated locations for NP_033164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK131875, AK134138, DQ158256
    Consensus CDS
    CCDS22085.1
    UniProtKB/Swiss-Prot
    O35903, Q9QYY6
    UniProtKB/TrEMBL
    Q3V2F3
    Related
    ENSMUSP00000024004.8, ENSMUST00000024004.9
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...

RNA

  1. NR_033527.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and includes two alternate 5' exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK132700, DQ158256
    Related
    ENSMUST00000155797.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4375207..4410020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508736.5XP_006508799.1  C-C motif chemokine 25 isoform X2

    UniProtKB/TrEMBL
    D3YWJ1
    Related
    ENSMUSP00000120719.3, ENSMUST00000127460.8
    Conserved Domains (1) summary
    cd01119
    Location:112173
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  2. XM_030243364.1XP_030099224.1  C-C motif chemokine 25 isoform X4

    Conserved Domains (1) summary
    cd01119
    Location:81142
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  3. XM_036153845.1XP_036009738.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  4. XM_036153847.1XP_036009740.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  5. XM_036153840.1XP_036009733.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  6. XM_036153843.1XP_036009736.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  7. XM_036153848.1XP_036009741.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  8. XM_036153841.1XP_036009734.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  9. XM_036153846.1XP_036009739.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  10. XM_011242043.3XP_011240345.3  C-C motif chemokine 25 isoform X1

    Conserved Domains (1) summary
    cd01119
    Location:117178
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  11. XM_011242044.4XP_011240346.3  C-C motif chemokine 25 isoform X3

    Conserved Domains (1) summary
    cd01119
    Location:86147
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  12. XM_011242045.3XP_011240347.1  C-C motif chemokine 25 isoform X5

    Conserved Domains (1) summary
    cd01119
    Location:45106
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  13. XM_036153844.1XP_036009737.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...
  14. XM_036153842.1XP_036009735.1  C-C motif chemokine 25 isoform X6

    UniProtKB/Swiss-Prot
    Q9QYY6
    Conserved Domains (1) summary
    cd01119
    Location:2889
    Chemokine_CC_DCCL; subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by ...