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CCL1 C-C motif chemokine ligand 1 [ Homo sapiens (human) ]

Gene ID: 6346, updated on 11-Apr-2024


Official Symbol
CCL1provided by HGNC
Official Full Name
C-C motif chemokine ligand 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000108702 MIM:182281; AllianceGenome:HGNC:10609
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P500; SISe; TCA3; I-309; SCYA1
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
Low expression observed in reference dataset See more
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Genomic context

See CCL1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (34360328..34363233, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (35307311..35310197, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (32687347..32690252, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 8 Neighboring gene C-C motif chemokine ligand 13 Neighboring gene uncharacterized LOC124903986 Neighboring gene NANOG hESC enhancer GRCh37_chr17:32736867-32737622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:32752329-32752830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:32770987-32771486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:32771890-32772390 Neighboring gene uncharacterized LOC105371738

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages PubMed
Tat tat HIV-1 Tat inhibits I-309 (CCL1) driven cell migration as demonstrated using Tat peptides containing CXC or CC-like sequences (Tat amino acids 25-27 and 30-31, respectively) PubMed
Vif vif HIV-1 Vif downregulates the expression of chemokine (C-C motif) ligand 1 (CCL1) in Vif-expression T cells PubMed
Vpr vpr HIV-1 Vpr downregulates the monocyte chemoattractant I-309) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
enables chemokine activity IDA
Inferred from Direct Assay
more info
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
located_in extracellular space IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
C-C motif chemokine 1
T lymphocyte-secreted protein I-309
chemokine (C-C motif) ligand 1
inflammatory cytokine I-309
small inducible cytokine A1 (I-309, homologous to mouse Tca-3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002981.2NP_002972.1  C-C motif chemokine 1 precursor

    See identical proteins and their annotated locations for NP_002972.1

    Status: REVIEWED

    Source sequence(s)
    AC011193, DA620119, M57502
    Consensus CDS
    B2R5G9, P22362, Q2M309
    ENSP00000225842.3, ENST00000225842.4
    Conserved Domains (1) summary
    Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    34360328..34363233 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060941.1 Alternate T2T-CHM13v2.0

    35307311..35310197 complement
    GenBank, FASTA, Sequence Viewer (Graphics)