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SCT secretin [ Homo sapiens (human) ]

Gene ID: 6343, updated on 27-Nov-2024

Summary

Official Symbol
SCTprovided by HGNC
Official Full Name
secretinprovided by HGNC
Primary source
HGNC:HGNC:10607
See related
Ensembl:ENSG00000070031 MIM:182099; AllianceGenome:HGNC:10607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]
Expression
Biased expression in duodenum (RPKM 7.1), small intestine (RPKM 1.4) and 2 other tissues See more
Orthologs
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Genomic context

See SCT in Genome Data Viewer
Location:
11p15.5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (626309..627181, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (674921..675793, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (626309..627181, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:612434-613028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:613623-614217 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:614812-615406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:620099-620704 Neighboring gene interferon regulatory factor 7 Neighboring gene cadherin related family member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:626715-627215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:635551-636086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:636087-636620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:637156-637689 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:637690-638224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:638225-638758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:638759-639293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:639294-639827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:640193-640804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:640805-641416 Neighboring gene Sharpr-MPRA regulatory region 3787 Neighboring gene dopamine receptor D4 Neighboring gene DEAF1 transcription factor Neighboring gene uncharacterized LOC124902603

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables digestive hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables hormone activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in diet induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryonic digestive tract development IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gastrin-induced gastric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pancreatic juice secretion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of pancreatic juice secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of somatostatin secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
secretin
Names
prepro-secretin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021920.4NP_068739.1  secretin preproprotein

    See identical proteins and their annotated locations for NP_068739.1

    Status: REVIEWED

    Source sequence(s)
    AP006284, HY019819, HY243621
    Consensus CDS
    CCDS7709.1
    UniProtKB/Swiss-Prot
    P09683
    Related
    ENSP00000176195.3, ENST00000176195.4
    Conserved Domains (1) summary
    smart00070
    Location:2854
    GLUCA; Glucagon like hormones

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    626309..627181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    156208..157080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    674921..675793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)