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SCT secretin [ Homo sapiens (human) ]

Gene ID: 6343, updated on 21-Dec-2019

Summary

Official Symbol
SCTprovided by HGNC
Official Full Name
secretinprovided by HGNC
Primary source
HGNC:HGNC:10607
See related
Ensembl:ENSG00000070031 MIM:182099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]
Expression
Biased expression in duodenum (RPKM 7.1), small intestine (RPKM 1.4) and 2 other tissues See more
Orthologs

Genomic context

See SCT in Genome Data Viewer
Location:
11p15.5
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (626095..627692, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (626313..627173, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 7 Neighboring gene cadherin related family member 5 Neighboring gene dopamine receptor D4 Neighboring gene DEAF1 transcription factor Neighboring gene transmembrane protein 80

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
digestive hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 
hormone activity NAS
Non-traceable Author Statement
more info
PubMed 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
diet induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic digestive tract development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gastrin-induced gastric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pancreatic juice secretion NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pancreatic juice secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of somatostatin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cellular_component ND
No biological Data available
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
secretin
Names
prepro-secretin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021920.4NP_068739.1  secretin preproprotein

    See identical proteins and their annotated locations for NP_068739.1

    Status: REVIEWED

    Source sequence(s)
    AP006284, HY019819, HY243621
    Consensus CDS
    CCDS7709.1
    UniProtKB/Swiss-Prot
    P09683
    Related
    ENSP00000176195.3, ENST00000176195.4
    Conserved Domains (1) summary
    smart00070
    Location:2854
    GLUCA; Glucagon like hormones

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    626095..627692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018109.1XP_016873598.1  secretin isoform X1

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    156208..157080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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