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Sct secretin [ Mus musculus (house mouse) ]

Gene ID: 20287, updated on 5-Jan-2023

Summary

Official Symbol
Sctprovided by MGI
Official Full Name
secretinprovided by MGI
Primary source
MGI:MGI:99466
See related
Ensembl:ENSMUSG00000038580 AllianceGenome:MGI:99466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone. [provided by RefSeq, Jul 2015]
Expression
Biased expression in placenta adult (RPKM 726.5), duodenum adult (RPKM 163.1) and 3 other tissues See more
Orthologs
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Genomic context

See Sct in Genome Data Viewer
Location:
7; 7 F5
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140858242..140859082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141278329..141279174, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 7 Neighboring gene cadherin-related family member 5 Neighboring gene dopamine receptor D4 Neighboring gene DEAF1, transcription factor Neighboring gene predicted gene, 53347

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables digestive hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dentate gyrus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in diet induced thermogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular water homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gastrin-induced gastric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gastrin-induced gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pancreatic juice secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of pancreatic juice secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of somatostatin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of somatostatin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of appetite IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287171.1NP_001274100.1  secretin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001274100.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC163434, AK145859, CF616255
    Consensus CDS
    CCDS72069.1
    UniProtKB/TrEMBL
    Q3UKU8, Q80ZS9
    Related
    ENSMUSP00000041519.7, ENSMUST00000046156.13
    Conserved Domains (1) summary
    smart00070
    Location:3258
    GLUCA; Glucagon like hormones
  2. NM_001309439.1NP_001296368.1  secretin isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in internal exons, including one in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC163434, AK145859, CF616255
    Consensus CDS
    CCDS85457.1
    UniProtKB/TrEMBL
    A0A1B0GS37, Q3UKU8
    Related
    ENSMUSP00000147780.2, ENSMUST00000211667.2
    Conserved Domains (1) summary
    cl27746
    Location:3258
    Hormone_2; Peptide hormone
  3. NM_011328.3NP_035458.1  secretin isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_035458.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC163434, AK145859, CF616255
    Consensus CDS
    CCDS40184.1
    UniProtKB/Swiss-Prot
    Q08535
    UniProtKB/TrEMBL
    Q3UKU8
    Related
    ENSMUSP00000128729.2, ENSMUST00000167790.3
    Conserved Domains (1) summary
    smart00070
    Location:3258
    GLUCA; Glucagon like hormones

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140858242..140859082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322065.3XP_017177554.1  secretin isoform X1

    UniProtKB/TrEMBL
    A0A1B0GS37
    Conserved Domains (1) summary
    cl27746
    Location:3258
    Hormone_2; Peptide hormone