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SAA2 serum amyloid A2 [ Homo sapiens (human) ]

Gene ID: 6289, updated on 12-Oct-2019

Summary

Official Symbol
SAA2provided by HGNC
Official Full Name
serum amyloid A2provided by HGNC
Primary source
HGNC:HGNC:10514
See related
Ensembl:ENSG00000134339 MIM:104751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAA; SAA1
Expression
Biased expression in liver (RPKM 216.6), fat (RPKM 172.8) and 1 other tissue See more
Orthologs

Genomic context

See SAA2 in Genome Data Viewer
Location:
11p15.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (18238236..18248668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18259780..18270221, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SLC25A51 pseudogene 4 Neighboring gene SAA2-SAA4 readthrough Neighboring gene serum amyloid A4, constitutive Neighboring gene RNA, 5S ribosomal pseudogene 333 Neighboring gene ST13, Hsp70 interacting protein pseudogene 5 Neighboring gene RNA, 5S ribosomal pseudogene 334 Neighboring gene serum amyloid A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough SAA2-SAA4

Readthrough gene: SAA2-SAA4, Included gene: SAA4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serum amyloid A-2 protein
Names
Serum amyloid A-1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127380.3NP_001120852.1  serum amyloid A-2 protein isoform b precursor

    See identical proteins and their annotated locations for NP_001120852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' exon, as compared to variant 1. The resulting isoform (b) has a shorter and different C-terminus, as compared to isoform a.
    Source sequence(s)
    AC090099, AK307163, CB241029
    Consensus CDS
    CCDS44548.1
    UniProtKB/Swiss-Prot
    P0DJI9
    Related
    ENSP00000416716.2, ENST00000414546.6
    Conserved Domains (1) summary
    cl02506
    Location:2577
    SAA; Serum amyloid A protein
  2. NM_030754.5NP_110381.2  serum amyloid A-2 protein isoform a precursor

    See identical proteins and their annotated locations for NP_110381.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC090099, BC020795, M23700, X51445
    Consensus CDS
    CCDS7833.1
    UniProtKB/Swiss-Prot
    P0DJI9
    Related
    ENSP00000256733.4, ENST00000256733.8
    Conserved Domains (1) summary
    pfam00277
    Location:25122
    SAA; Serum amyloid A protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    18238236..18248668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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