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SAA2 serum amyloid A2 [ Homo sapiens (human) ]

Gene ID: 6289, updated on 11-Jun-2021

Summary

Official Symbol
SAA2provided by HGNC
Official Full Name
serum amyloid A2provided by HGNC
Primary source
HGNC:HGNC:10514
See related
Ensembl:ENSG00000134339 MIM:104751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAA; SAA1
Summary
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. [provided by RefSeq, Jul 2020]
Expression
Biased expression in liver (RPKM 216.6), fat (RPKM 172.8) and 1 other tissue See more
Orthologs
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Genomic context

See SAA2 in Genome Data Viewer
Location:
11p15.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (18238236..18248668, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18259783..18270215, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SLC25A51 pseudogene 4 Neighboring gene SAA2-SAA4 readthrough Neighboring gene serum amyloid A4, constitutive Neighboring gene Sharpr-MPRA regulatory regions 9378 and 7495 Neighboring gene RNA, 5S ribosomal pseudogene 333 Neighboring gene ST13, Hsp70 interacting protein pseudogene 5 Neighboring gene RNA, 5S ribosomal pseudogene 334 Neighboring gene serum amyloid A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough SAA2-SAA4

Readthrough gene: SAA2-SAA4, Included gene: SAA4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serum amyloid A-2 protein
Names
Serum amyloid A-1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127380.3NP_001120852.1  serum amyloid A-2 protein isoform b preproprotein

    See identical proteins and their annotated locations for NP_001120852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has an alternate 3' exon compared to variant 3. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC090099, AK307163, CB241029
    Consensus CDS
    CCDS44548.1
    UniProtKB/Swiss-Prot
    P0DJI9
    Related
    ENSP00000416716.2, ENST00000414546.6
    Conserved Domains (1) summary
    cl02506
    Location:2577
    SAA; Serum amyloid A protein
  2. NM_001385666.1NP_001372595.1  serum amyloid A-2 protein isoform a preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC090099
    Related
    ENSP00000437162.1, ENST00000529528.5
    Conserved Domains (1) summary
    pfam00277
    Location:25122
    SAA; Serum amyloid A protein
  3. NM_001385667.1NP_001372596.1  serum amyloid A-2 protein isoform b preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 3' exon compared to variant 3. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC090099
    Conserved Domains (1) summary
    cl02506
    Location:2577
    SAA; Serum amyloid A protein
  4. NM_001385668.1NP_001372597.1  serum amyloid A-2 protein isoform c preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC090099
  5. NM_001385669.1NP_001372598.1  serum amyloid A-2 protein isoform d preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC090099
    Conserved Domains (1) summary
    cl02506
    Location:2580
    SAA; Serum amyloid A protein
  6. NM_001385670.1NP_001372599.1  serum amyloid A-2 protein isoform e preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC090099
    Conserved Domains (1) summary
    cl02506
    Location:2591
    SAA; Serum amyloid A protein
  7. NM_001385671.1NP_001372600.1  serum amyloid A-2 protein isoform f

    Status: REVIEWED

    Source sequence(s)
    AC090099
    Conserved Domains (1) summary
    pfam00277
    Location:188
    SAA; Serum amyloid A protein
  8. NM_001385672.1NP_001372601.1  serum amyloid A-2 protein isoform g preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC090099
    Conserved Domains (1) summary
    cl02506
    Location:2577
    SAA; Serum amyloid A protein
  9. NM_001385673.1NP_001372602.1  serum amyloid A-2 protein isoform h

    Status: REVIEWED

    Source sequence(s)
    AC090099
  10. NM_030754.5NP_110381.2  serum amyloid A-2 protein isoform a preproprotein

    See identical proteins and their annotated locations for NP_110381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AC090099, BC020795, M23700, X51445
    Consensus CDS
    CCDS7833.1
    UniProtKB/Swiss-Prot
    P0DJI9
    Related
    ENSP00000256733.5, ENST00000256733.9
    Conserved Domains (1) summary
    pfam00277
    Location:25122
    SAA; Serum amyloid A protein

RNA

  1. NR_169749.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090099
  2. NR_169750.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090099

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    18238236..18248668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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