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S100A9 S100 calcium binding protein A9 [ Homo sapiens (human) ]

Gene ID: 6280, updated on 9-Sep-2018

Summary

Official Symbol
S100A9provided by HGNC
Official Full Name
S100 calcium binding protein A9provided by HGNC
Primary source
HGNC:HGNC:10499
See related
Ensembl:ENSG00000163220 MIM:123886; Vega:OTTHUMG00000013125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014]
Expression
Biased expression in bone marrow (RPKM 7440.5), esophagus (RPKM 5956.4) and 1 other tissue See more
Orthologs

Genomic context

See S100A9 in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (153357854..153361027)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153330330..153333503)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidoglycan recognition protein 3 Neighboring gene peptidoglycan recognition protein 4 Neighboring gene RNA, U6 small nuclear 160, pseudogene Neighboring gene S100 calcium binding protein A12 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Clinical HIV-1 infection decreases S100A9 in blood plasma of patients with symptomatic neurocognitive disorders PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL1 and megakaryocytes in obesity, organism-specific biosystem (from WikiPathways)
    IL1 and megakaryocytes in obesity, organism-specific biosystemSchematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory a...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Metal sequestration by antimicrobial proteins, organism-specific biosystem (from REACTOME)
    Metal sequestration by antimicrobial proteins, organism-specific biosystemMetals are necessary for all forms of life including microorganisms, evidenced by the fact that metal cations are constituents of approximately 40% of all proteins crystallized to date (Waldron KJ et...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
    Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RAGE receptor binding TAS
Traceable Author Statement
more info
PubMed 
Toll-like receptor 4 binding TAS
Traceable Author Statement
more info
PubMed 
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid binding TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
microtubule binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
astrocyte development IEA
Inferred from Electronic Annotation
more info
 
autophagy IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
chemokine production TAS
Traceable Author Statement
more info
PubMed 
cytokine production TAS
Traceable Author Statement
more info
PubMed 
defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
defense response to fungus TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
modification of morphology or physiology of other organism IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil aggregation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptidyl-cysteine S-trans-nitrosylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of integrin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
sequestering of zinc ion TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein S100-A9
Names
MRP-14
calgranulin B
calprotectin L1H subunit
leukocyte L1 complex heavy chain
migration inhibitory factor-related protein 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002965.3NP_002956.1  protein S100-A9

    See identical proteins and their annotated locations for NP_002956.1

    Status: REVIEWED

    Source sequence(s)
    AF086362, BC047681, X06233
    Consensus CDS
    CCDS1036.1
    UniProtKB/Swiss-Prot
    P06702
    Related
    ENSP00000357727.3, OTTHUMP00000015331, ENST00000368738.3, OTTHUMT00000036793
    Conserved Domains (1) summary
    cd05030
    Location:694
    calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    153357854..153361027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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