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RXRB retinoid X receptor beta [ Homo sapiens (human) ]

Gene ID: 6257, updated on 5-Jul-2025
Official Symbol
RXRBprovided by HGNC
Official Full Name
retinoid X receptor betaprovided by HGNC
Primary source
HGNC:HGNC:10478
See related
Ensembl:ENSG00000204231 MIM:180246; AllianceGenome:HGNC:10478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NR2B2; DAUDI6; RCoR-1; RXRbeta; H-2RIIBP; RXR-beta
Summary
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in thyroid (RPKM 13.3), spleen (RPKM 12.9) and 25 other tissues See more
Orthologs
NEW
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See RXRB in Genome Data Viewer
Location:
6p21.32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (33193588..33200853, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (33014941..33022206, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33161365..33168630, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375021 Neighboring gene HLA complex group 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:33131677-33132178 Neighboring gene collagen type XI alpha 2 chain Neighboring gene ReSE screen-validated silencer GRCh37_chr6:33165434-33165634 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:33168171-33168672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33168673-33169174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33169175-33169676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33172262-33173144 Neighboring gene RNY4 pseudogene 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:33173145-33174025 Neighboring gene solute carrier family 39 member 7 Neighboring gene hydroxysteroid 17-beta dehydrogenase 8

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef induces loss of F-actin assembly and inhibits retinoid receptor-mediated transcription PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC1831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinoic acid-responsive element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hormone-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear receptor-mediated steroid hormone signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of bone mineralization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of vitamin D receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ventricular cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of RNA polymerase II transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
retinoic acid receptor RXR-beta
Names
MHC class I promoter binding protein
nuclear receptor subfamily 2 group B member 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023374.1 RefSeqGene

    Range
    4991..12068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270401.2NP_001257330.1  retinoic acid receptor RXR-beta isoform 1

    See identical proteins and their annotated locations for NP_001257330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK225842, AL645940, AW473828, DC425042
    Consensus CDS
    CCDS59007.1
    UniProtKB/TrEMBL
    A0A0S2Z570, J3JS71
    Related
    ENSP00000363817.4, ENST00000374685.8
    Conserved Domains (2) summary
    cd06943
    Location:298515
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:204279
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
  2. NM_001291989.2NP_001278918.1  retinoic acid receptor RXR-beta isoform 3

    See identical proteins and their annotated locations for NP_001278918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK225842, AK302125, AL645940
    UniProtKB/TrEMBL
    A0A0G2JKR7, B7Z7J5
    Conserved Domains (2) summary
    cd06943
    Location:108325
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:1489
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
  3. NM_021976.5NP_068811.1  retinoic acid receptor RXR-beta isoform 2

    See identical proteins and their annotated locations for NP_068811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL645940, AW473828, BC001167, BE704198, DC425042
    Consensus CDS
    CCDS4768.1
    UniProtKB/Swiss-Prot
    P28702, P28703, Q59G65, Q5JP92, Q5STQ1
    UniProtKB/TrEMBL
    J3JS71, Q5STP9
    Related
    ENSP00000363812.3, ENST00000374680.4
    Conserved Domains (3) summary
    cd06943
    Location:298511
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:204279
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
    pfam11825
    Location:135189
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    33193588..33200853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419238.1XP_047275194.1  retinoic acid receptor RXR-beta isoform X2

  2. XM_005249278.4XP_005249335.1  retinoic acid receptor RXR-beta isoform X1

    See identical proteins and their annotated locations for XP_005249335.1

    Conserved Domains (2) summary
    cd06943
    Location:202419
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily
    cd06956
    Location:108183
    NR_DBD_RXR; DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers
  3. XM_047419239.1XP_047275195.1  retinoic acid receptor RXR-beta isoform X3

    UniProtKB/TrEMBL
    Q06310, Q30190
    Conserved Domains (1) summary
    cd06943
    Location:29246
    NR_LBD_RXR_like; The ligand binding domain of the retinoid X receptor and Ultraspiracle, members of nuclear receptor superfamily

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    4605095..4612358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329847.1XP_054185822.1  retinoic acid receptor RXR-beta isoform X2

  2. XM_054329846.1XP_054185821.1  retinoic acid receptor RXR-beta isoform X1

  3. XM_054329848.1XP_054185823.1  retinoic acid receptor RXR-beta isoform X3

    UniProtKB/TrEMBL
    Q06310, Q30190

RNA

  1. XR_008485662.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    4437087..4444352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330330.1XP_054186305.1  retinoic acid receptor RXR-beta isoform X2

  2. XM_054330329.1XP_054186304.1  retinoic acid receptor RXR-beta isoform X1

  3. XM_054330331.1XP_054186306.1  retinoic acid receptor RXR-beta isoform X3

    UniProtKB/TrEMBL
    Q06310, Q30190

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    4613060..4620326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330621.1XP_054186596.1  retinoic acid receptor RXR-beta isoform X2

  2. XM_054330620.1XP_054186595.1  retinoic acid receptor RXR-beta isoform X1

  3. XM_054330622.1XP_054186597.1  retinoic acid receptor RXR-beta isoform X3

    UniProtKB/TrEMBL
    Q06310, Q30190

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    4629544..4636806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330846.1XP_054186821.1  retinoic acid receptor RXR-beta isoform X2

  2. XM_054330845.1XP_054186820.1  retinoic acid receptor RXR-beta isoform X1

  3. XM_054330847.1XP_054186822.1  retinoic acid receptor RXR-beta isoform X3

    UniProtKB/TrEMBL
    Q06310, Q30190

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    4387991..4395257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331108.1XP_054187083.1  retinoic acid receptor RXR-beta isoform X2

  2. XM_054331107.1XP_054187082.1  retinoic acid receptor RXR-beta isoform X1

  3. XM_054331109.1XP_054187084.1  retinoic acid receptor RXR-beta isoform X3

    UniProtKB/TrEMBL
    Q06310, Q30190

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    33014941..33022206 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356193.1XP_054212168.1  retinoic acid receptor RXR-beta isoform X2

  2. XM_054356192.1XP_054212167.1  retinoic acid receptor RXR-beta isoform X1

  3. XM_054356194.1XP_054212169.1  retinoic acid receptor RXR-beta isoform X3

    UniProtKB/TrEMBL
    Q06310, Q30190

RNA

  1. XR_008487422.1 RNA Sequence