Format

Send to:

Choose Destination

CLIP1 CAP-Gly domain containing linker protein 1 [ Homo sapiens (human) ]

Gene ID: 6249, updated on 13-Jan-2020

Summary

Official Symbol
CLIP1provided by HGNC
Official Full Name
CAP-Gly domain containing linker protein 1provided by HGNC
Primary source
HGNC:HGNC:10461
See related
Ensembl:ENSG00000130779 MIM:179838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSN; CLIP; CYLN1; CLIP170; CLIP-170
Summary
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in thyroid (RPKM 36.8), esophagus (RPKM 33.7) and 25 other tissues See more
Orthologs

Genomic context

See CLIP1 in Genome Data Viewer
Location:
12q24.31
Exon count:
30
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (122271431..122422956, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (122755981..122907179, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101593348 Neighboring gene diablo IAP-binding mitochondrial protein Neighboring gene VPS33A core subunit of CORVET and HOPS complexes Neighboring gene coiled-coil domain containing 150 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 1 Neighboring gene CLIP1 antisense RNA 1 Neighboring gene zinc finger CCHC-type containing 8 Neighboring gene arginine and serine rich coiled-coil 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131604

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding NAS
Non-traceable Author Statement
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport into plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome TAS
Traceable Author Statement
more info
PubMed 
intermediate filament TAS
Traceable Author Statement
more info
PubMed 
kinetochore TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with macropinosome IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CAP-Gly domain-containing linker protein 1
Names
cytoplasmic linker protein 1
cytoplasmic linker protein 170 alpha-2
cytoplasmic linker protein CLIP-170
restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030352.1 RefSeqGene

    Range
    5001..156136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001247997.1NP_001234926.1  CAP-Gly domain-containing linker protein 1 isoform c

    See identical proteins and their annotated locations for NP_001234926.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC048338, BC126305, CB305431, M97501
    Consensus CDS
    CCDS58285.1
    UniProtKB/Swiss-Prot
    P30622
    Related
    ENSP00000479322.1, ENST00000620786.4
    Conserved Domains (5) summary
    COG5244
    Location:212812
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:215278
    CAP_GLY; CAP-Gly domain
    pfam07851
    Location:567666
    TMPIT; TMPIT-like protein
    pfam10174
    Location:4741255
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam16641
    Location:14161432
    CLIP1_ZNF; CLIP1 zinc knuckle
  2. NM_002956.2NP_002947.1  CAP-Gly domain-containing linker protein 1 isoform a

    See identical proteins and their annotated locations for NP_002947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AK126990, BM998166, M97501, X64838
    Consensus CDS
    CCDS9232.1
    UniProtKB/Swiss-Prot
    P30622
    UniProtKB/TrEMBL
    A0A024RBR1, B3KXA5
    Related
    ENSP00000351665.2, ENST00000358808.6
    Conserved Domains (4) summary
    TIGR04523
    Location:4291147
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01302
    Location:215278
    CAP_GLY; CAP-Gly domain
    pfam07851
    Location:556655
    TMPIT; TMPIT-like protein
    pfam16641
    Location:14051421
    CLIP1_ZNF; CLIP1 zinc knuckle
  3. NM_198240.2NP_937883.1  CAP-Gly domain-containing linker protein 1 isoform b

    See identical proteins and their annotated locations for NP_937883.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AC048338, AC127002, AK126990, BM998166, M97501, X64838
    Consensus CDS
    CCDS9233.1
    UniProtKB/Swiss-Prot
    P30622
    UniProtKB/TrEMBL
    B3KXA5
    Related
    ENSP00000445531.1, ENST00000537178.5
    Conserved Domains (5) summary
    COG1196
    Location:6091250
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5244
    Location:212866
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:215278
    CAP_GLY; CAP-Gly domain
    pfam07851
    Location:521620
    TMPIT; TMPIT-like protein
    pfam16641
    Location:13701386
    CLIP1_ZNF; CLIP1 zinc knuckle

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    122271431..122422956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019790.1XP_016875279.1  CAP-Gly domain-containing linker protein 1 isoform X6

    UniProtKB/Swiss-Prot
    P30622
    Conserved Domains (5) summary
    COG1196
    Location:6091250
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5244
    Location:212866
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:215278
    CAP_GLY; CAP-Gly domain
    pfam07851
    Location:521620
    TMPIT; TMPIT-like protein
    pfam16641
    Location:13701386
    CLIP1_ZNF; CLIP1 zinc knuckle
  2. XM_017019788.2XP_016875277.1  CAP-Gly domain-containing linker protein 1 isoform X5

  3. XM_017019791.2XP_016875280.1  CAP-Gly domain-containing linker protein 1 isoform X7

  4. XM_006719552.4XP_006719615.1  CAP-Gly domain-containing linker protein 1 isoform X2

    Conserved Domains (4) summary
    TIGR04523
    Location:4291147
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01302
    Location:215278
    CAP_GLY; CAP-Gly domain
    pfam07851
    Location:556655
    TMPIT; TMPIT-like protein
    pfam16641
    Location:14071423
    CLIP1_ZNF; CLIP1 zinc knuckle
  5. XM_017019787.2XP_016875276.1  CAP-Gly domain-containing linker protein 1 isoform X4

  6. XM_005253593.3XP_005253650.1  CAP-Gly domain-containing linker protein 1 isoform X1

    Conserved Domains (5) summary
    COG5244
    Location:212812
    NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:215278
    CAP_GLY; CAP-Gly domain
    pfam07851
    Location:567666
    TMPIT; TMPIT-like protein
    pfam10174
    Location:4741255
    Cast; RIM-binding protein of the cytomatrix active zone
    pfam16641
    Location:14181434
    CLIP1_ZNF; CLIP1 zinc knuckle
  7. XM_017019792.2XP_016875281.1  CAP-Gly domain-containing linker protein 1 isoform X8

  8. XM_017019786.1XP_016875275.1  CAP-Gly domain-containing linker protein 1 isoform X3

    UniProtKB/Swiss-Prot
    P30622
    UniProtKB/TrEMBL
    A0A024RBR1
    Conserved Domains (4) summary
    TIGR04523
    Location:4291147
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam01302
    Location:215278
    CAP_GLY; CAP-Gly domain
    pfam07851
    Location:556655
    TMPIT; TMPIT-like protein
    pfam16641
    Location:14051421
    CLIP1_ZNF; CLIP1 zinc knuckle
  9. XM_017019789.1XP_016875278.1  CAP-Gly domain-containing linker protein 1 isoform X5

Support Center