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Clip1 CAP-GLY domain containing linker protein 1 [ Mus musculus (house mouse) ]

Gene ID: 56430, updated on 9-Mar-2023

Summary

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Official Symbol
Clip1provided by MGI
Official Full Name
CAP-GLY domain containing linker protein 1provided by MGI
Primary source
MGI:MGI:1928401
See related
Ensembl:ENSMUSG00000049550 AllianceGenome:MGI:1928401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsn; CYLN1; Clip50; restin; CLIP170; CLIP-170; mKIAA4046; 1110007I12Rik; 4631429H07Rik
Summary
Enables microtubule plus-end binding activity. Acts upstream of or within protein transport into plasma membrane raft. Located in microtubule plus-end and nuclear envelope. Is expressed in several structures, including brain; early conceptus; heart; and spleen. Orthologous to human CLIP1 (CAP-Gly domain containing linker protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.9), CNS E18 (RPKM 9.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Clip1 in Genome Data Viewer
Location:
5; 5 F
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123715857..123822527, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123577794..123684606, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene microRNA 7647 Neighboring gene VPS33A CORVET/HOPS core subunit Neighboring gene predicted gene, 24840 Neighboring gene zinc finger, CCHC domain containing 8 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation controls autoinhibition of cytoplasmic linker protein-170. Lee HS, et al. Mol Biol Cell, 2010 Aug 1. PMID 20519438, Free PMC Article
  2. Cytoplasmic linker protein-170 enhances spreading and phagocytosis in activated macrophages by stabilizing microtubules. Binker MG, et al. J Immunol, 2007 Sep 15. PMID 17785815
  3. The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis. Akhmanova A, et al. Genes Dev, 2005 Oct 15. PMID 16230537, Free PMC Article
  4. Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. Lansbergen G, et al. J Cell Biol, 2004 Sep 27. PMID 15381688, Free PMC Article
  5. [Restin expressed in vivo suppresses the growth of tumors in nude mice]. Xu R, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2002 Sep. PMID 12198558

See all (60) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pregnenolone-methyl-ether enhances CLIP170 and microtubule functions improving spine maturation and hippocampal deficits related to CDKL5 deficiency.
    Title: Pregnenolone-methyl-ether enhances CLIP170 and microtubule functions improving spine maturation and hippocampal deficits related to CDKL5 deficiency.
  2. AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.
    Title: AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170.
  3. Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
    Title: Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.
  4. we report an unexpected finding that CLIP170 negatively regulates TLR4 signaling by the targeted ubiquitination and degradation of TIRAP. Furthermore, we observed that CLIP170 expression is modulated by LPS to maintain the cellular homeostasis.
    Title: Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP.
  5. Drosophila CLIP-190 (and potentially also mouse CLIP-170) does not possess a significant role in the axon growth-promoting microtubule machinery.
    Title: Drosophila CLIP-190 and mammalian CLIP-170 display reduced microtubule plus end association in the nervous system.
  6. Cytoplasmic linker protein 170 was ubiquitously expressed in mouse kidney, liver, lung, normal non-atherosclerotic aorta, and atherosclerotic aorta and was partly localized in the vascular endothelium.
    Title: Identification of a cytoplasmic linker protein as a potential target for neovascularization.
  7. Phosphorylation regulates CLIP-170 conformational changes resulting in its autoinhibition.
    Title: Phosphorylation controls autoinhibition of cytoplasmic linker protein-170.
  8. Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends.
    Title: Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends.
  9. CLIP170 is a key regulator of microtubule stabilization that is required for enhanced cell spreading and phagocytosis in activated macrophages.
    Title: Cytoplasmic linker protein-170 enhances spreading and phagocytosis in activated macrophages by stabilizing microtubules.
  10. Restin expressed in vivo suppresses the growth of tumors in nude mice
    Title: [Restin expressed in vivo suppresses the growth of tumors in nude mice].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4046

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport into plasma membrane raft IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with macropinosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
CAP-Gly domain-containing linker protein 1
Names
Clip 170
Reed-Steinberg cell-espressed intermediate filament-associated protein
cytoplasmic linker protein 170
cytoplasmic linker protein 50
restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291229.1 → NP_001278158.1  CAP-Gly domain-containing linker protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC129569
    Consensus CDS
    CCDS71663.1
    UniProtKB/Swiss-Prot
    Q922J3
    Related
    ENSMUSP00000107190.2, ENSMUST00000111564.8
    Conserved Domains (3) summary
    pfam01302
    Location:214 → 277
    CAP_GLY; CAP-Gly domain
    pfam15964
    Location:413 → 1070
    CCCAP; Centrosomal colon cancer autoantigen protein family
    pfam16641
    Location:1293 → 1309
    CLIP1_ZNF; CLIP1 zinc knuckle

  2. NM_001347468.1 → NP_001334397.1  CAP-Gly domain-containing linker protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has several in-frame differences compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC129569
    Consensus CDS
    CCDS84958.1
    UniProtKB/TrEMBL
    D3Z3M7
    Related
    ENSMUSP00000068241.6, ENSMUST00000063905.12

  3. NM_001359220.1 → NP_001346149.1  CAP-Gly domain-containing linker protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC129569
    Conserved Domains (3) summary
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1367 → 1383
    CLIP1_ZNF; CLIP1 zinc knuckle
    cl25732
    Location:404 → 1298
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001359221.1 → NP_001346150.1  CAP-Gly domain-containing linker protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC129569
    Related
    ENSMUSP00000121425.2, ENSMUST00000137363.8
    Conserved Domains (3) summary
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1291 → 1307
    CLIP1_ZNF; CLIP1 zinc knuckle
    cl25732
    Location:404 → 1222
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001359222.1 → NP_001346151.1  CAP-Gly domain-containing linker protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC129569
    Conserved Domains (3) summary
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1256 → 1272
    CLIP1_ZNF; CLIP1 zinc knuckle
    cl25732
    Location:404 → 1187
    SMC_N; RecF/RecN/SMC N terminal domain

  6. NM_001359223.1 → NP_001346152.1  CAP-Gly domain-containing linker protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC129569
    Conserved Domains (2) summary
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:351 → 1093
    SMC_N; RecF/RecN/SMC N terminal domain

  7. NM_001359224.1 → NP_001346153.1  CAP-Gly domain-containing linker protein 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC129569
    Conserved Domains (2) summary
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    cl25732
    Location:369 → 1134
    SMC_N; RecF/RecN/SMC N terminal domain

  8. NM_019765.5 → NP_062739.2  CAP-Gly domain-containing linker protein 1 isoform a

    See identical proteins and their annotated locations for NP_062739.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC129569
    Consensus CDS
    CCDS19667.1
    UniProtKB/Swiss-Prot
    Q571L7, Q922J3
    Related
    ENSMUSP00000107192.3, ENSMUST00000111566.9
    Conserved Domains (3) summary
    pfam05483
    Location:344 → 1112
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    pfam01302
    Location:214 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1369 → 1385
    CLIP1_ZNF; CLIP1 zinc knuckle

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123715857..123822527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254713.2 → XP_030110573.1  CAP-Gly domain-containing linker protein 1 isoform X10

    Conserved Domains (4) summary
    COG1196
    Location:649 → 1473
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK03918
    Location:338 → 857
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2103 → 2119
    CLIP1_ZNF; CLIP1 zinc knuckle

  2. XM_006530416.5 → XP_006530479.1  CAP-Gly domain-containing linker protein 1 isoform X8

    Conserved Domains (4) summary
    COG1196
    Location:660 → 1484
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:338 → 927
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2114 → 2130
    CLIP1_ZNF; CLIP1 zinc knuckle

  3. XM_036165355.1 → XP_036021248.1  CAP-Gly domain-containing linker protein 1 isoform X38

    Conserved Domains (3) summary
    COG1196
    Location:404 → 1187
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1254 → 1270
    CLIP1_ZNF; CLIP1 zinc knuckle

  4. XM_017321029.3 → XP_017176518.1  CAP-Gly domain-containing linker protein 1 isoform X37

    Conserved Domains (3) summary
    COG1196
    Location:369 → 1194
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1263 → 1279
    CLIP1_ZNF; CLIP1 zinc knuckle

  5. XM_036165352.1 → XP_036021245.1  CAP-Gly domain-containing linker protein 1 isoform X34

    Conserved Domains (3) summary
    COG1196
    Location:420 → 1226
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1295 → 1311
    CLIP1_ZNF; CLIP1 zinc knuckle

  6. XM_006530423.5 → XP_006530486.1  CAP-Gly domain-containing linker protein 1 isoform X32

    Conserved Domains (3) summary
    COG1196
    Location:420 → 1233
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1302 → 1318
    CLIP1_ZNF; CLIP1 zinc knuckle

  7. XM_006530419.5 → XP_006530482.1  CAP-Gly domain-containing linker protein 1 isoform X12

    Conserved Domains (5) summary
    COG1196
    Location:420 → 1223
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5022
    Location:1640 → 2016
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:900 → 1797
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2058 → 2074
    CLIP1_ZNF; CLIP1 zinc knuckle

  8. XM_030254716.2 → XP_030110576.1  CAP-Gly domain-containing linker protein 1 isoform X23

    Conserved Domains (3) summary
    COG1196
    Location:420 → 1309
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1378 → 1394
    CLIP1_ZNF; CLIP1 zinc knuckle

  9. XM_006530415.5 → XP_006530478.1  CAP-Gly domain-containing linker protein 1 isoform X7

    Conserved Domains (4) summary
    COG1196
    Location:680 → 1504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:352 → 947
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2134 → 2150
    CLIP1_ZNF; CLIP1 zinc knuckle

  10. XM_036165353.1 → XP_036021246.1  CAP-Gly domain-containing linker protein 1 isoform X35

    Conserved Domains (3) summary
    COG1196
    Location:404 → 1222
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1289 → 1305
    CLIP1_ZNF; CLIP1 zinc knuckle

  11. XM_017321020.3 → XP_017176509.1  CAP-Gly domain-containing linker protein 1 isoform X13

    Conserved Domains (5) summary
    COG1196
    Location:351 → 1078
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5022
    Location:1636 → 2012
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:896 → 1793
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2054 → 2070
    CLIP1_ZNF; CLIP1 zinc knuckle

  12. XM_036165346.1 → XP_036021239.1  CAP-Gly domain-containing linker protein 1 isoform X27

    Conserved Domains (3) summary
    COG1196
    Location:351 → 1076
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1328 → 1344
    CLIP1_ZNF; CLIP1 zinc knuckle

  13. XM_036165344.1 → XP_036021237.1  CAP-Gly domain-containing linker protein 1 isoform X26

    Conserved Domains (4) summary
    COG1196
    Location:462 → 1261
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 525
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1330 → 1346
    CLIP1_ZNF; CLIP1 zinc knuckle

  14. XM_006530422.5 → XP_006530485.1  CAP-Gly domain-containing linker protein 1 isoform X20

    UniProtKB/TrEMBL
    D3Z2Z1
    Related
    ENSMUSP00000107186.2, ENSMUST00000111561.8
    Conserved Domains (3) summary
    COG1196
    Location:351 → 1152
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1404 → 1420
    CLIP1_ZNF; CLIP1 zinc knuckle

  15. XM_036165337.1 → XP_036021230.1  CAP-Gly domain-containing linker protein 1 isoform X19

    Conserved Domains (4) summary
    COG1196
    Location:462 → 1337
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 525
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1406 → 1422
    CLIP1_ZNF; CLIP1 zinc knuckle

  16. XM_036165336.1 → XP_036021229.1  CAP-Gly domain-containing linker protein 1 isoform X18

    Conserved Domains (4) summary
    COG1196
    Location:351 → 1152
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1413 → 1429
    CLIP1_ZNF; CLIP1 zinc knuckle
    NF033930
    Location:1058 → 1338
    pneumo_PspA; pneumococcal surface protein A

  17. XM_006530412.5 → XP_006530475.1  CAP-Gly domain-containing linker protein 1 isoform X5

    Conserved Domains (4) summary
    COG1196
    Location:715 → 1539
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:351 → 982
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2169 → 2185
    CLIP1_ZNF; CLIP1 zinc knuckle

  18. XM_036165354.1 → XP_036021247.1  CAP-Gly domain-containing linker protein 1 isoform X36

    Conserved Domains (3) summary
    COG1196
    Location:404 → 1198
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1265 → 1281
    CLIP1_ZNF; CLIP1 zinc knuckle

  19. XM_036165348.1 → XP_036021241.1  CAP-Gly domain-containing linker protein 1 isoform X30

    Conserved Domains (4) summary
    COG1196
    Location:477 → 1237
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1304 → 1320
    CLIP1_ZNF; CLIP1 zinc knuckle
    NF033930
    Location:336 → 603
    pneumo_PspA; pneumococcal surface protein A

  20. XM_036165347.1 → XP_036021240.1  CAP-Gly domain-containing linker protein 1 isoform X29

    Conserved Domains (4) summary
    COG1196
    Location:477 → 1237
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1306 → 1322
    CLIP1_ZNF; CLIP1 zinc knuckle
    NF033930
    Location:336 → 603
    pneumo_PspA; pneumococcal surface protein A

  21. XM_036165339.1 → XP_036021232.1  CAP-Gly domain-containing linker protein 1 isoform X22

    Conserved Domains (4) summary
    COG1196
    Location:477 → 1313
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1380 → 1396
    CLIP1_ZNF; CLIP1 zinc knuckle
    NF033930
    Location:349 → 603
    pneumo_PspA; pneumococcal surface protein A

  22. XM_036165338.1 → XP_036021231.1  CAP-Gly domain-containing linker protein 1 isoform X21

    Conserved Domains (4) summary
    COG1196
    Location:477 → 1313
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1382 → 1398
    CLIP1_ZNF; CLIP1 zinc knuckle
    NF033930
    Location:349 → 603
    pneumo_PspA; pneumococcal surface protein A

  23. XM_006530413.5 → XP_006530476.1  CAP-Gly domain-containing linker protein 1 isoform X6

    Conserved Domains (4) summary
    COG1196
    Location:691 → 1515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:352 → 958
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2145 → 2161
    CLIP1_ZNF; CLIP1 zinc knuckle

  24. XM_036165351.1 → XP_036021244.1  CAP-Gly domain-containing linker protein 1 isoform X33

    Conserved Domains (3) summary
    COG1196
    Location:420 → 1233
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1300 → 1316
    CLIP1_ZNF; CLIP1 zinc knuckle

  25. XM_036165350.1 → XP_036021243.1  CAP-Gly domain-containing linker protein 1 isoform X31

    Conserved Domains (3) summary
    COG1196
    Location:420 → 1233
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1302 → 1318
    CLIP1_ZNF; CLIP1 zinc knuckle

  26. XM_017321026.3 → XP_017176515.1  CAP-Gly domain-containing linker protein 1 isoform X28

    Conserved Domains (3) summary
    COG1196
    Location:404 → 1240
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1309 → 1325
    CLIP1_ZNF; CLIP1 zinc knuckle

  27. XM_006530418.5 → XP_006530481.1  CAP-Gly domain-containing linker protein 1 isoform X11

    Conserved Domains (5) summary
    COG1196
    Location:351 → 1089
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5022
    Location:1647 → 2023
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:907 → 1804
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2065 → 2081
    CLIP1_ZNF; CLIP1 zinc knuckle

  28. XM_036165342.1 → XP_036021235.1  CAP-Gly domain-containing linker protein 1 isoform X25

    Conserved Domains (4) summary
    COG1196
    Location:473 → 1272
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 536
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1339 → 1355
    CLIP1_ZNF; CLIP1 zinc knuckle

  29. XM_036165341.1 → XP_036021234.1  CAP-Gly domain-containing linker protein 1 isoform X24

    Conserved Domains (4) summary
    COG1196
    Location:473 → 1272
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 536
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1341 → 1357
    CLIP1_ZNF; CLIP1 zinc knuckle

  30. XM_006530417.5 → XP_006530480.1  CAP-Gly domain-containing linker protein 1 isoform X9

    Conserved Domains (6) summary
    COG1196
    Location:473 → 1269
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5022
    Location:1686 → 2062
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:946 → 1843
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2104 → 2120
    CLIP1_ZNF; CLIP1 zinc knuckle
    pfam17380
    Location:343 → 533
    DUF5401; Family of unknown function (DUF5401)

  31. XM_006530421.5 → XP_006530484.1  CAP-Gly domain-containing linker protein 1 isoform X17

    UniProtKB/TrEMBL
    F8WIA1
    Related
    ENSMUSP00000031382.8, ENSMUST00000031382.14
    Conserved Domains (4) summary
    COG1196
    Location:473 → 1348
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 536
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1415 → 1431
    CLIP1_ZNF; CLIP1 zinc knuckle

  32. XM_017321022.3 → XP_017176511.1  CAP-Gly domain-containing linker protein 1 isoform X16

    Conserved Domains (4) summary
    COG1196
    Location:473 → 1348
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1417 → 1433
    CLIP1_ZNF; CLIP1 zinc knuckle
    pfam17380
    Location:343 → 533
    DUF5401; Family of unknown function (DUF5401)

  33. XM_036165334.1 → XP_036021227.1  CAP-Gly domain-containing linker protein 1 isoform X15

    Conserved Domains (4) summary
    COG1196
    Location:473 → 1355
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 536
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1422 → 1438
    CLIP1_ZNF; CLIP1 zinc knuckle

  34. XM_006530420.5 → XP_006530483.1  CAP-Gly domain-containing linker protein 1 isoform X14

    Conserved Domains (4) summary
    COG1196
    Location:473 → 1355
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1424 → 1440
    CLIP1_ZNF; CLIP1 zinc knuckle
    pfam17380
    Location:343 → 533
    DUF5401; Family of unknown function (DUF5401)

  35. XM_006530411.5 → XP_006530474.1  CAP-Gly domain-containing linker protein 1 isoform X4

    Conserved Domains (4) summary
    COG1196
    Location:726 → 1550
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1141 → 2095
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2171 → 2187
    CLIP1_ZNF; CLIP1 zinc knuckle

  36. XM_006530410.5 → XP_006530473.1  CAP-Gly domain-containing linker protein 1 isoform X3

    Conserved Domains (5) summary
    COG1196
    Location:726 → 1550
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:351 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam09787
    Location:1911 → 2129
    Golgin_A5; Golgin subfamily A member 5
    pfam16641
    Location:2173 → 2189
    CLIP1_ZNF; CLIP1 zinc knuckle

  37. XM_006530409.5 → XP_006530472.1  CAP-Gly domain-containing linker protein 1 isoform X2

    Conserved Domains (4) summary
    COG1196
    Location:726 → 1550
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:351 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2178 → 2194
    CLIP1_ZNF; CLIP1 zinc knuckle

  38. XM_006530407.5 → XP_006530470.1  CAP-Gly domain-containing linker protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006530470.1

    Conserved Domains (4) summary
    COG1196
    Location:726 → 1550
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:351 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2180 → 2196
    CLIP1_ZNF; CLIP1 zinc knuckle

  39. XM_030254714.1 → XP_030110574.1  CAP-Gly domain-containing linker protein 1 isoform X12

    Conserved Domains (5) summary
    COG1196
    Location:420 → 1223
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5022
    Location:1640 → 2016
    COG5022; Myosin heavy chain [General function prediction only]
    TIGR02168
    Location:900 → 1797
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2058 → 2074
    CLIP1_ZNF; CLIP1 zinc knuckle

  40. XM_030254712.1 → XP_030110572.1  CAP-Gly domain-containing linker protein 1 isoform X7

    Conserved Domains (4) summary
    COG1196
    Location:680 → 1504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:352 → 947
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2134 → 2150
    CLIP1_ZNF; CLIP1 zinc knuckle

  41. XM_011248233.3 → XP_011246535.1  CAP-Gly domain-containing linker protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011246535.1

    Conserved Domains (4) summary
    COG1196
    Location:726 → 1550
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:351 → 993
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:2180 → 2196
    CLIP1_ZNF; CLIP1 zinc knuckle

  42. XM_036165349.1 → XP_036021242.1  CAP-Gly domain-containing linker protein 1 isoform X30

    Conserved Domains (4) summary
    COG1196
    Location:477 → 1237
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1304 → 1320
    CLIP1_ZNF; CLIP1 zinc knuckle
    NF033930
    Location:336 → 603
    pneumo_PspA; pneumococcal surface protein A

  43. XM_036165343.1 → XP_036021236.1  CAP-Gly domain-containing linker protein 1 isoform X25

    Conserved Domains (4) summary
    COG1196
    Location:473 → 1272
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 536
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1339 → 1355
    CLIP1_ZNF; CLIP1 zinc knuckle

  44. XM_036165335.1 → XP_036021228.1  CAP-Gly domain-containing linker protein 1 isoform X17

    UniProtKB/TrEMBL
    F8WIA1
    Conserved Domains (4) summary
    COG1196
    Location:473 → 1348
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam17380
    Location:356 → 536
    DUF5401; Family of unknown function (DUF5401)
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1415 → 1431
    CLIP1_ZNF; CLIP1 zinc knuckle

  45. XM_036165340.1 → XP_036021233.1  CAP-Gly domain-containing linker protein 1 isoform X22

    Conserved Domains (4) summary
    COG1196
    Location:477 → 1313
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam01302
    Location:213 → 277
    CAP_GLY; CAP-Gly domain
    pfam16641
    Location:1380 → 1396
    CLIP1_ZNF; CLIP1 zinc knuckle
    NF033930
    Location:349 → 603
    pneumo_PspA; pneumococcal surface protein A
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922J3.1 GenPept UniProtKB/Swiss-Prot:Q922J3

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