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RRBP1 ribosome binding protein 1 [ Homo sapiens (human) ]

Gene ID: 6238, updated on 5-Jan-2020

Summary

Official Symbol
RRBP1provided by HGNC
Official Full Name
ribosome binding protein 1provided by HGNC
Primary source
HGNC:HGNC:10448
See related
Ensembl:ENSG00000125844 MIM:601418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRp; hES; ES130; ES/130
Summary
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in thyroid (RPKM 72.8), colon (RPKM 63.4) and 25 other tissues See more
Orthologs

Genomic context

See RRBP1 in Genome Data Viewer
Location:
20p12.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (17613678..17682283, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (17594323..17662934, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 69 Neighboring gene ras homolog family member G pseudogene Neighboring gene destrin, actin depolymerizing factor Neighboring gene uncharacterized LOC105372547 Neighboring gene BANF family member 2 Neighboring gene uncharacterized LOC107985440

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of ribosome binding protein 1 (RRBP1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36146, MGC157720, MGC157721, DKFZp586A1420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
osteoblast differentiation HDA PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
ribosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ribosome-binding protein 1
Names
180 kDa ribosome receptor homolog
ES/130-related protein
ribosome binding protein 1 homolog 180kDa (dog)
ribosome receptor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042576.1NP_001036041.1  ribosome-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001036041.1

    Status: REVIEWED

    Source sequence(s)
    AF006751, AL132765
    Consensus CDS
    CCDS13128.1
    UniProtKB/Swiss-Prot
    Q9P2E9
    Related
    ENSP00000367038.2, ENST00000377807.6
    Conserved Domains (2) summary
    TIGR02168
    Location:265962
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05104
    Location:33171
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
  2. NM_001365613.2NP_001352542.1  ribosome-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL132765, KF456852
    Related
    ENSP00000367044.1, ENST00000377813.6
    Conserved Domains (3) summary
    pfam05104
    Location:33165
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    cl25732
    Location:6981395
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26511
    Location:2901020
    Neuromodulin_N; Gap junction protein N-terminal region
  3. NM_004587.2NP_004578.2  ribosome-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_004578.2

    Status: REVIEWED

    Source sequence(s)
    AF006751, AL132765
    Consensus CDS
    CCDS13128.1
    UniProtKB/Swiss-Prot
    Q9P2E9
    Related
    ENSP00000354045.4, ENST00000360807.8
    Conserved Domains (2) summary
    TIGR02168
    Location:265962
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05104
    Location:33171
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    17613678..17682283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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