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RRAS RAS related [ Homo sapiens (human) ]

Gene ID: 6237, updated on 7-Jun-2020

Summary

Official Symbol
RRASprovided by HGNC
Official Full Name
RAS relatedprovided by HGNC
Primary source
HGNC:HGNC:10447
See related
Ensembl:ENSG00000126458 MIM:165090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R-Ras
Summary
The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in fat (RPKM 75.3), lung (RPKM 63.7) and 23 other tissues See more
Orthologs

Genomic context

See RRAS in Genome Data Viewer
Location:
19q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49635292..49640143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50138552..50143400, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 2 Neighboring gene proline rich 12 Neighboring gene SR-related CTD associated factor 1 Neighboring gene interferon regulatory factor 3 Neighboring gene BCL2 like 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GDP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell-matrix adhesion via fibronectin IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein R-Ras
Names
oncogene RRAS
p23
ras family small GTP binding protein R-Ras
related RAS viral (r-ras) oncogene homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042222.1 RefSeqGene

    Range
    5001..9852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006270.5NP_006261.1  ras-related protein R-Ras

    See identical proteins and their annotated locations for NP_006261.1

    Status: REVIEWED

    Source sequence(s)
    BC016286, BC016318
    Consensus CDS
    CCDS12774.1
    UniProtKB/Swiss-Prot
    P10301
    UniProtKB/TrEMBL
    A0A024QZF2
    Related
    ENSP00000246792.2, ENST00000246792.4
    Conserved Domains (1) summary
    cd04145
    Location:28191
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49635292..49640143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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