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Rras related RAS viral (r-ras) oncogene [ Mus musculus (house mouse) ]

Gene ID: 20130, updated on 28-Dec-2022

Summary

Official Symbol
Rrasprovided by MGI
Official Full Name
related RAS viral (r-ras) oncogeneprovided by MGI
Primary source
MGI:MGI:98179
See related
Ensembl:ENSMUSG00000038387 AllianceGenome:MGI:98179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rras1
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within negative regulation of cell migration. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RRAS (RAS related). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 109.9), bladder adult (RPKM 109.8) and 25 other tissues See more
Orthologs
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Genomic context

See Rras in Genome Data Viewer
Location:
7 B3; 7 29.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44665686..44671070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45017942..45021646)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene microRNA 7054 Neighboring gene proline rich 12 Neighboring gene proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 Neighboring gene nitric oxide synthase interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129444, MGC129445

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein R-Ras
Names
Harvey rat sarcoma oncogene, subgroup R
p23
NP_001347061.1
NP_001347062.1
NP_033127.1
XP_036008706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360132.1NP_001347061.1  ras-related protein R-Ras isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC126256
    Conserved Domains (1) summary
    cl21455
    Location:2141
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001360133.1NP_001347062.1  ras-related protein R-Ras isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC126256
    Conserved Domains (1) summary
    cl21455
    Location:199
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_009101.3NP_033127.1  ras-related protein R-Ras isoform 1

    See identical proteins and their annotated locations for NP_033127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC126256, BC009105
    Consensus CDS
    CCDS21226.1
    UniProtKB/Swiss-Prot
    P10833
    UniProtKB/TrEMBL
    A0A6P5PW91, Q3U1N3
    Related
    ENSMUSP00000042150.8, ENSMUST00000044111.10
    Conserved Domains (1) summary
    cd04145
    Location:28191
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44665686..44671070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152813.1XP_036008706.1  ras-related protein R-Ras isoform X1

    UniProtKB/Swiss-Prot
    P10833
    UniProtKB/TrEMBL
    A0A6P5PW91, Q3U1N3
    Conserved Domains (1) summary
    cd04145
    Location:28191
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3