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RPS27 ribosomal protein S27 [ Homo sapiens (human) ]

Gene ID: 6232, updated on 5-Jan-2020

Summary

Official Symbol
RPS27provided by HGNC
Official Full Name
ribosomal protein S27provided by HGNC
Primary source
HGNC:HGNC:10416
See related
Ensembl:ENSG00000177954 MIM:603702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S27; MPS1; DBA17; MPS-1
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia (DBA). Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2018]
Expression
Ubiquitous expression in ovary (RPKM 2236.6), lymph node (RPKM 1431.7) and 25 other tissues See more
Orthologs

Genomic context

See RPS27 in Genome Data Viewer
Location:
1q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153990755..153992155)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153963239..153964631)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3 like 4 Neighboring gene jumping translocation breakpoint Neighboring gene RAB13, member RAS oncogene family Neighboring gene nucleoporin 210 like Neighboring gene ribosomal protein L34 pseudogene 5 Neighboring gene RNA, U6 small nuclear 179, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ribosomal protein S27 (RPS27) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
ribosome NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein S27
Names
metallopan-stimulin 1
metallopanstimulin 1
small ribosomal subunit protein eS27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053102.2 RefSeqGene

    Range
    5008..6401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1158

mRNA and Protein(s)

  1. NM_001030.6NP_001021.1  40S ribosomal protein S27 isoform 1

    See identical proteins and their annotated locations for NP_001021.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AJ572583, BC070219, D28454
    Consensus CDS
    CCDS1059.1
    UniProtKB/Swiss-Prot
    P42677
    Related
    ENSP00000499044.1, ENST00000651669.1
    Conserved Domains (1) summary
    PLN00209
    Location:682
    PLN00209; ribosomal protein S27; Provisional
  2. NM_001349946.1NP_001336875.1  40S ribosomal protein S27 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in its 5' UTR and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AJ572583, BC070219, CD175039, CN270933
    Conserved Domains (1) summary
    cl00897
    Location:150
    Ribosomal_S27e; Ribosomal protein S27
  3. NM_001349947.1NP_001336876.1  40S ribosomal protein S27 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) retains an intron in its 5' UTR compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AJ572583, BC070219, BP276426, CD175039
    Conserved Domains (1) summary
    cl00897
    Location:150
    Ribosomal_S27e; Ribosomal protein S27

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153990755..153992155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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