Format

Send to:

Choose Destination

RPS14 ribosomal protein S14 [ Homo sapiens (human) ]

Gene ID: 6208, updated on 4-Nov-2018

Summary

Official Symbol
RPS14provided by HGNC
Official Full Name
ribosomal protein S14provided by HGNC
Primary source
HGNC:HGNC:10387
See related
Ensembl:ENSG00000164587 MIM:130620; Vega:OTTHUMG00000130080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S14; EMTB
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 306.3), bone marrow (RPKM 258.9) and 25 other tissues See more
Orthologs

Genomic context

See RPS14 in Genome Data Viewer
Location:
5q33.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (150444229..150449756, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149822712..149829351, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene CD74 molecule Neighboring gene NDST1 antisense RNA 1 Neighboring gene N-deacetylase and N-sulfotransferase 1 Neighboring gene synaptopodin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
5q- syndrome
MedGen: C0740302 OMIM: 153550 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 5'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
small ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
maturation of SSU-rRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
rRNA processing TAS
Traceable Author Statement
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal small subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosomal small subunit assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IC
Inferred by Curator
more info
PubMed 
translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit HDA PubMed 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
40S ribosomal protein S14
Names
emetine resistance
small ribosomal subunit protein uS11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042287.1 RefSeqGene

    Range
    5001..10528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025070.1NP_001020241.1  40S ribosomal protein S14

    See identical proteins and their annotated locations for NP_001020241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a small segment in the 5' UTR, as compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AA467888, AC011388, BM454896
    Consensus CDS
    CCDS4307.1
    UniProtKB/Swiss-Prot
    P62263
    Related
    ENSP00000385958.3, OTTHUMP00000224343, ENST00000401695.8, OTTHUMT00000374309
    Conserved Domains (1) summary
    PTZ00129
    Location:1140
    PTZ00129; 40S ribosomal protein S14; Provisional
  2. NM_001025071.1NP_001020242.1  40S ribosomal protein S14

    See identical proteins and their annotated locations for NP_001020242.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AA467888, AC011388, BM557014
    Consensus CDS
    CCDS4307.1
    UniProtKB/Swiss-Prot
    P62263
    Related
    ENSP00000311028.5, ENST00000312037.6
    Conserved Domains (1) summary
    PTZ00129
    Location:1140
    PTZ00129; 40S ribosomal protein S14; Provisional
  3. NM_005617.3NP_005608.1  40S ribosomal protein S14

    See identical proteins and their annotated locations for NP_005608.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a big segment in the 5' UTR, as compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AA467888, AC011388, BC006784
    Consensus CDS
    CCDS4307.1
    UniProtKB/Swiss-Prot
    P62263
    Related
    ENSP00000385425.1, OTTHUMP00000160559, ENST00000407193.6, OTTHUMT00000252373
    Conserved Domains (1) summary
    PTZ00129
    Location:1140
    PTZ00129; 40S ribosomal protein S14; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    150444229..150449756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center