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RPS11 ribosomal protein S11 [ Homo sapiens (human) ]

Gene ID: 6205, updated on 3-Nov-2024

Summary

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Official Symbol
RPS11provided by HGNC
Official Full Name
ribosomal protein S11provided by HGNC
Primary source
HGNC:HGNC:10384
See related
Ensembl:ENSG00000142534 MIM:180471; AllianceGenome:HGNC:10384
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S11; uS17
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in ovary (RPKM 1700.9), bone marrow (RPKM 1027.8) and 25 other tissues See more
Orthologs
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Genomic context

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See RPS11 in Genome Data Viewer
Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49496434..49499708)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52496418..52499692)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49999691..50002965)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13a Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49993864-49994467 Neighboring gene small nucleolar RNA, C/D box 34 Neighboring gene small nucleolar RNA, C/D box 35A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14945 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49998436-49999208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14947 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50002301-50003072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50003073-50003845 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50003846-50004617 Neighboring gene microRNA 150 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Noncoordinated expression of S6, S11, and S14 ribosomal protein genes in leukemic blast cells. Ferrari S, et al. Cancer Res, 1990 Sep 15. PMID 1697501
  2. Sequence of a cloned cDNA encoding human ribosomal protein S11. Lott JB, et al. Nucleic Acids Res, 1988 Feb 11. PMID 3267208, Free PMC Article
  3. Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients. Yong WH, et al. PLoS One, 2015. PMID 26506620, Free PMC Article
  4. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. Feo S, et al. Genomics, 1992 May. PMID 1577483
  5. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. Vanderwerf SM, et al. Blood, 2009 Dec 17. PMID 19850743, Free PMC Article

See all (256) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. increased expression of RPS11 and RPS20 predicts shorter patient survival. treatment-resistant GSC clones are clinically relevant cells that represent resistant tumorigenic clones from patient tumors and that their properties
    Title: Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit HDA PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleolus HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS17
Names
40S ribosomal protein S11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015.5 → NP_001006.1  small ribosomal subunit protein uS17

    See identical proteins and their annotated locations for NP_001006.1

    Status: REVIEWED

    Source sequence(s)
    AK311809, BI550467
    Consensus CDS
    CCDS12769.1
    UniProtKB/Swiss-Prot
    B2R4F5, P04643, P62280, Q498Y6, Q6IRY0
    Related
    ENSP00000270625.1, ENST00000270625.7
    Conserved Domains (1) summary
    PTZ00241
    Location:1 → 158
    PTZ00241; 40S ribosomal protein S11; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49496434..49499708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52496418..52499692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62280.3 GenPept UniProtKB/Swiss-Prot:P62280

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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