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RPS11 ribosomal protein S11 [ Homo sapiens (human) ]

Gene ID: 6205, updated on 9-Jun-2024

Summary

Official Symbol
RPS11provided by HGNC
Official Full Name
ribosomal protein S11provided by HGNC
Primary source
HGNC:HGNC:10384
See related
Ensembl:ENSG00000142534 MIM:180471; AllianceGenome:HGNC:10384
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S11; uS17
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in ovary (RPKM 1700.9), bone marrow (RPKM 1027.8) and 25 other tissues See more
Orthologs
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Genomic context

See RPS11 in Genome Data Viewer
Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49496434..49499708)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52496418..52499692)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49999691..50002965)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13a Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49993864-49994467 Neighboring gene small nucleolar RNA, C/D box 34 Neighboring gene small nucleolar RNA, C/D box 35A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14945 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49998436-49999208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14947 Neighboring gene small nucleolar RNA, C/D box 35B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50002301-50003072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50003073-50003845 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50003846-50004617 Neighboring gene microRNA 150 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translation IC
Inferred by Curator
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
small ribosomal subunit protein uS17
Names
40S ribosomal protein S11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015.5NP_001006.1  small ribosomal subunit protein uS17

    See identical proteins and their annotated locations for NP_001006.1

    Status: REVIEWED

    Source sequence(s)
    AK311809, BI550467
    Consensus CDS
    CCDS12769.1
    UniProtKB/Swiss-Prot
    B2R4F5, P04643, P62280, Q498Y6, Q6IRY0
    Related
    ENSP00000270625.1, ENST00000270625.7
    Conserved Domains (1) summary
    PTZ00241
    Location:1158
    PTZ00241; 40S ribosomal protein S11; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49496434..49499708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52496418..52499692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)