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RPL37A ribosomal protein L37a [ Homo sapiens (human) ]

Gene ID: 6168, updated on 24-Nov-2020

Summary

Official Symbol
RPL37Aprovided by HGNC
Official Full Name
ribosomal protein L37aprovided by HGNC
Primary source
HGNC:HGNC:10348
See related
Ensembl:ENSG00000197756 MIM:613314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L37A
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 975.8), fat (RPKM 601.9) and 25 other tissues See more
Orthologs

Genomic context

See RPL37A in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (216498844..216504086)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217363520..217366190)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SMARCAL1 antisense RNA 1 Neighboring gene uncharacterized LOC107985984 Neighboring gene Sharpr-MPRA regulatory region 13820 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 Neighboring gene RPL37A divergent transcript Neighboring gene uncharacterized LOC101928156 Neighboring gene uncharacterized LOC101928180 Neighboring gene uncharacterized LOC105373871

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL37A as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13357, MGC74786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60S ribosomal protein L37a
Names
large ribosomal subunit protein eL43

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000998.5NP_000989.1  60S ribosomal protein L37a

    See identical proteins and their annotated locations for NP_000989.1

    Status: REVIEWED

    Source sequence(s)
    AC073321, BC014262, CD249666, L06499
    Consensus CDS
    CCDS2404.1
    UniProtKB/Swiss-Prot
    P61513
    Related
    ENSP00000418082.1, ENST00000491306.6
    Conserved Domains (1) summary
    pfam01780
    Location:488
    Ribosomal_L37ae; Ribosomal L37ae protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    216498844..216504086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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