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RPL21 ribosomal protein L21 [ Homo sapiens (human) ]

Gene ID: 6144, updated on 4-Apr-2021

Summary

Official Symbol
RPL21provided by HGNC
Official Full Name
ribosomal protein L21provided by HGNC
Primary source
HGNC:HGNC:10313
See related
Ensembl:ENSG00000122026 MIM:603636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L21; HYPT12
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 1199.3), lymph node (RPKM 872.5) and 25 other tissues See more
Orthologs
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Genomic context

See RPL21 in Genome Data Viewer
Location:
13q12.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (27251558..27256568)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (27825695..27830705)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene USP12 antisense RNA 2 (head to head) Neighboring gene long intergenic non-protein coding RNA 2340 Neighboring gene long intergenic non-protein coding RNA 412 Neighboring gene small nucleolar RNA, C/D box 102 Neighboring gene small nucleolar RNA, H/ACA box 27 Neighboring gene RAS like family 11 member A Neighboring gene RNA, U6 small nuclear 70, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study.
GeneReviews: Not available
Hypotrichosis 12
MedGen: C4014563 OMIM: 615885 GeneReviews: Not available
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Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27458, MGC71252, MGC104274, MGC104275, DKFZp686C06101

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
60S ribosomal protein L21
Names
large ribosomal subunit protein eL21
NP_000973.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046927.1 RefSeqGene

    Range
    5001..10014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000982.4NP_000973.2  60S ribosomal protein L21

    See identical proteins and their annotated locations for NP_000973.2

    Status: REVIEWED

    Source sequence(s)
    AL159977
    Consensus CDS
    CCDS9320.1
    UniProtKB/Swiss-Prot
    P46778
    UniProtKB/TrEMBL
    Q6IAX2
    Related
    ENSP00000346027.4, ENST00000311549.10
    Conserved Domains (1) summary
    PTZ00189
    Location:1160
    PTZ00189; 60S ribosomal protein L21; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    27251558..27256568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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