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RPL9 ribosomal protein L9 [ Homo sapiens (human) ]

Gene ID: 6133, updated on 7-Jun-2020

Summary

Official Symbol
RPL9provided by HGNC
Official Full Name
ribosomal protein L9provided by HGNC
Primary source
HGNC:HGNC:10369
See related
Ensembl:ENSG00000163682 MIM:603686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L9; NPC-A-16
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in ovary (RPKM 1269.0), bone marrow (RPKM 646.0) and 25 other tissues See more
Orthologs

Genomic context

See RPL9 in Genome Data Viewer
Location:
4p14
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (39454124..39458948, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (39455744..39460568, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 887, pseudogene Neighboring gene klotho beta Neighboring gene microRNA 5591 Neighboring gene Sharpr-MPRA regulatory region 11886 Neighboring gene lipoic acid synthetase Neighboring gene WD repeat domain 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L9 (RPL9), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L9 (RPL9) at amino acid residues 42-43 and 45-46 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27456, MGC15545, DKFZp313J1510

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
nucleus HDA PubMed 
ribosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L9
Names
large ribosomal subunit protein uL6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052985.1 RefSeqGene

    Range
    5027..9825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000661.5NP_000652.2  60S ribosomal protein L9

    See identical proteins and their annotated locations for NP_000652.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and the predominant variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC031906, BC066318, BM841336
    Consensus CDS
    CCDS3452.1
    UniProtKB/Swiss-Prot
    P32969
    UniProtKB/TrEMBL
    Q53Z07
    Related
    ENSP00000346022.7, ENST00000295955.13
    Conserved Domains (1) summary
    cl30086
    Location:1191
    Ribosomal_L6; Ribosomal protein L6
  2. NM_001024921.3NP_001020092.1  60S ribosomal protein L9

    See identical proteins and their annotated locations for NP_001020092.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternative splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL039355, AY376242, BC031906, BM841336
    Consensus CDS
    CCDS3452.1
    UniProtKB/Swiss-Prot
    P32969
    UniProtKB/TrEMBL
    Q53Z07
    Related
    ENSP00000400467.2, ENST00000449470.6
    Conserved Domains (1) summary
    cl30086
    Location:1191
    Ribosomal_L6; Ribosomal protein L6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    39454124..39458948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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