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RPL8 ribosomal protein L8 [ Homo sapiens (human) ]

Gene ID: 6132, updated on 7-Jun-2020

Summary

Official Symbol
RPL8provided by HGNC
Official Full Name
ribosomal protein L8provided by HGNC
Primary source
HGNC:HGNC:10368
See related
Ensembl:ENSG00000161016 MIM:604177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L8
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 817.1), colon (RPKM 466.9) and 25 other tissues See more
Orthologs

Genomic context

See RPL8 in Genome Data Viewer
Location:
8q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144789769..144792390, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146015152..146017805, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375805 Neighboring gene zinc finger protein 34 Neighboring gene RNA, 7SL, cytoplasmic 395, pseudogene Neighboring gene microRNA 6850 Neighboring gene zinc finger protein 517 Neighboring gene uncharacterized LOC100130027 Neighboring gene zinc finger protein 7 Neighboring gene COMM domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L8 (RPL8), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
polysomal ribosome IDA
Inferred from Direct Assay
more info
PubMed 
postsynapse EXP
Inferred from Experiment
more info
PubMed 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
60S ribosomal protein L8
Names
large ribosomal subunit protein uL2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000973.5NP_000964.1  60S ribosomal protein L8

    See identical proteins and their annotated locations for NP_000964.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC093064
    Consensus CDS
    CCDS6433.1
    UniProtKB/Swiss-Prot
    P62917
    Related
    ENSP00000262584.3, ENST00000262584.7
    Conserved Domains (1) summary
    PTZ00180
    Location:1254
    PTZ00180; 60S ribosomal protein L8; Provisional
  2. NM_001317771.2NP_001304700.1  60S ribosomal protein L8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AF235103, BM783910, BQ929065, CB128790
    Consensus CDS
    CCDS6433.1
    UniProtKB/Swiss-Prot
    P62917
    Conserved Domains (1) summary
    PTZ00180
    Location:1254
    PTZ00180; 60S ribosomal protein L8; Provisional
  3. NM_001317782.2NP_001304711.1  60S ribosomal protein L8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) retains an intron in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AF235103, BC030151, BG480561, CB128790
    Consensus CDS
    CCDS6433.1
    UniProtKB/Swiss-Prot
    P62917
    Related
    ENSP00000433464.2, ENST00000528957.5
    Conserved Domains (1) summary
    PTZ00180
    Location:1254
    PTZ00180; 60S ribosomal protein L8; Provisional
  4. NM_033301.3NP_150644.1  60S ribosomal protein L8

    See identical proteins and their annotated locations for NP_150644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AF235103, BC012197, BC030151, CB128790
    Consensus CDS
    CCDS6433.1
    UniProtKB/Swiss-Prot
    P62917
    Related
    ENSP00000378378.2, ENST00000394920.6
    Conserved Domains (1) summary
    PTZ00180
    Location:1254
    PTZ00180; 60S ribosomal protein L8; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144789769..144792390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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