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RPL7 ribosomal protein L7 [ Homo sapiens (human) ]

Gene ID: 6129, updated on 3-Nov-2024

Summary

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Official Symbol
RPL7provided by HGNC
Official Full Name
ribosomal protein L7provided by HGNC
Primary source
HGNC:HGNC:10363
See related
Ensembl:ENSG00000147604 MIM:604166; AllianceGenome:HGNC:10363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L7; uL30; humL7-1
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 918.2), bone marrow (RPKM 482.7) and 25 other tissues See more
Orthologs
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Genomic context

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See RPL7 in Genome Data Viewer
Location:
8q21.11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (73290242..73294466, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (73719762..73723986, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74202477..74206701, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375901 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74152441-74153040 Neighboring gene chromosome 8 open reading frame 89 Neighboring gene peroxiredoxin like 2A pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74197691-74198192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74198193-74198692 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205120-74205828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:74205829-74206536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:74211031-74211531 Neighboring gene NANOG hESC enhancer GRCh37_chr8:74216479-74216980 Neighboring gene retinol dehydrogenase 10 Neighboring gene RDH10 antisense RNA 1 Neighboring gene uncharacterized LOC105375899

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of eukaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune disease. von Mikecz A, et al. Immunobiology, 1994 Dec. PMID 7750987
  2. Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. Neumann F, et al. Nucleic Acids Res, 1995 Jan 25. PMID 7862521, Free PMC Article
  3. Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function. Ko JR, et al. FEBS Lett, 2006 Jul 10. PMID 16797011
  4. Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association. Wu WC, et al. FEBS Lett, 2007 Feb 20. PMID 17258209
  5. Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling. Mekdad HE, et al. Retrovirology, 2016 Aug 11. PMID 27515235, Free PMC Article

See all (294) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The nucleic acid chaperone activity of the HIV-1 Gag polyprotein is boosted by its cellular partner RPL7: a kinetic study.
    Title: The nucleic acid chaperone activity of the HIV-1 Gag polyprotein is boosted by its cellular partner RPL7: a kinetic study.
  2. HIV-1 Gag NC domain interacts with the ribosomal protein RPL7 endowed with nucleic acid chaperone activity, favoring the notion that RPL7 could be a Gag helper chaperoning factor possibly contributing to the start of Gag assembly
    Title: Characterization of the interaction between the HIV-1 Gag structural polyprotein and the cellular ribosomal protein L7 and its implication in viral nucleic acid remodeling.
  3. In case of L7, importin beta2 or importin beta3 are preferentially used by clusters with a high import efficiency.
    Title: The quantitative assessment of the role played by basic amino acid clusters in the nuclear uptake of human ribosomal protein L7.
  4. RPL7 gene expression is decreased in follicular variant of papillary thyroid carcinoma.
    Title: Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.
  5. importin beta3 is essential for the nuclear import of RPL7. The import is mediated via the multifaceted basic amino acid clusters present in the NH(2)-region of RPL7, and is RanGTP-dependent
    Title: Importin β3 mediates the nuclear import of human ribosomal protein L7 through its interaction with the multifaceted basic clusters of L7.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. L7-endoplasmic reticulum-binding nature could be one of multiple factors that allow a nascent peptide-less ribosome to remain at the endoplasmic reticulum.
    Title: Human ribosomal protein L7 displays an ER binding property and is involved in ribosome-ER association.
  8. Combining with the phylogenic findings from homologous sequence alignment, the NH2-region of L7, besides being as a eukaryotic expansion segment, can be excluded from building a functional eukaryotic ribosome.
    Title: Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L7 (RPL7), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L7 (RPL7) at amino acid residues 3-4 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleolus HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL30
Names
60S ribosomal protein L7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000971.4 → NP_000962.2  large ribosomal subunit protein uL30 isoform 1

    See identical proteins and their annotated locations for NP_000962.2

    Status: REVIEWED

    Source sequence(s)
    AC111149, BC009599, X52967
    Consensus CDS
    CCDS6212.1
    UniProtKB/Swiss-Prot
    A8K504, P18124, Q15289, Q3KQU0, Q5I0X1, Q6IBM9
    UniProtKB/TrEMBL
    O95036
    Related
    ENSP00000339795.2, ENST00000352983.7
    Conserved Domains (1) summary
    TIGR01310
    Location:16 → 248
    uL30_euk; 60S ribosomal protein uL30, eukaryotic form

  2. NM_001363737.2 → NP_001350666.1  large ribosomal subunit protein uL30 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC111149
    Consensus CDS
    CCDS87615.1
    UniProtKB/TrEMBL
    A8MUD9, O95036
    Related
    ENSP00000379729.1, ENST00000396465.5
    Conserved Domains (1) summary
    TIGR01310
    Location:3 → 208
    uL30_euk; 60S ribosomal protein uL30, eukaryotic form

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    73290242..73294466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    73719762..73723986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18124.1 GenPept UniProtKB/Swiss-Prot:P18124

Gene LinkOut

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Chemical Information
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