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RPL5 ribosomal protein L5 [ Homo sapiens (human) ]

Gene ID: 6125, updated on 11-Jun-2021

Summary

Official Symbol
RPL5provided by HGNC
Official Full Name
ribosomal protein L5provided by HGNC
Primary source
HGNC:HGNC:10360
See related
Ensembl:ENSG00000122406 MIM:603634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L5; uL18; MSTP030; PPP1R135
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in ovary (RPKM 1433.7), thyroid (RPKM 620.7) and 25 other tissues See more
Orthologs
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Genomic context

See RPL5 in Genome Data Viewer
Location:
1p22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (92831986..92841924)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93297543..93307481)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ecotropic viral integration site 5 Neighboring gene cyclin J pseudogene 2 Neighboring gene H3 histone pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene divergent protein kinase domain 1A Neighboring gene small nucleolar RNA, H/ACA box 66 Neighboring gene meiotic nuclear divisions 1 homolog (S. cerevisiae) pseudogene Neighboring gene RNA, U6 small nuclear 970, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diamond-Blackfan anemia 6
MedGen: C2931850 OMIM: 612561 GeneReviews: Diamond-Blackfan Anemia
not available
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available
Risk alleles for multiple sclerosis identified by a genomewide study.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L5 (RPL5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L5 (RPL5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L5 (RPL5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein L5 (RPL5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Rev rev ribosomal protein L5 interacts with eukaryotic initiation factor 5A (eIF-5A) as a cofactor for the Rev nuclear export activity of eIF-5A PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L5 (RPL5) at amino acid residues 135-136 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117339

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5S rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5S rRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of ribosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
enables ubiquitin ligase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of protein neddylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing TAS
Traceable Author Statement
more info
 
involved_in regulation of signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translational initiation TAS
Traceable Author Statement
more info
 
involved_in viral transcription TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60S ribosomal protein L5
Names
large ribosomal subunit protein uL18
protein phosphatase 1, regulatory subunit 135
NP_000960.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011779.2 RefSeqGene

    Range
    5055..14939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1155

mRNA and Protein(s)

  1. NM_000969.5NP_000960.2  60S ribosomal protein L5

    See identical proteins and their annotated locations for NP_000960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AF113210, BP247508, N67963
    Consensus CDS
    CCDS741.1
    UniProtKB/Swiss-Prot
    P46777
    UniProtKB/TrEMBL
    A2RUM7
    Related
    ENSP00000359345.2, ENST00000370321.8
    Conserved Domains (1) summary
    PTZ00069
    Location:1295
    PTZ00069; 60S ribosomal protein L5; Provisional

RNA

  1. NR_146333.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL162740, BC001882, BP247508, N67963

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    92831986..92841924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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