HAND2 heart and neural crest derivatives expressed 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HAND2provided by VGNC
Official Full Name: heart and neural crest derivatives expressed 2provided by VGNC
Primary source: VGNC:VGNC:58305
See related: Ensembl:ENSCAFG00845017182
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: DHAND
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	25	NC_051829.1 (24303930..24306779, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	25	NC_006607.4 (24791105..24793938, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	25	NC_049246.1 (24290187..24293030, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	25	NC_049285.1 (24249725..24252576, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	25	NC_049766.1 (24141364..24144207, complement)

Chromosome 25 - NC_051829.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Hand2 (e-PCR), detects polymorphism
- UniSTS:238134

WI-12683 (e-PCR)
- UniSTS:2450

UniSTS:478956 (e-PCR)
- UniSTS:478956

Hand2 (e-PCR), detects polymorphism
- UniSTS:478956

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heart- and neural crest derivatives-expressed protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051829.1 Reference ROS_Cfam_1.0

Range

24303930..24306779 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038435206.1 → XP_038291134.1 heart- and neural crest derivatives-expressed protein 2

UniProtKB/TrEMBL

A0A8C0KHD4, A0A8C0P2Z2, A0A8I3PA17

Related

ENSCAFP00845023837.1, ENSCAFT00845030394.1

Conserved Domains (1) summary

cd11471
Location:100 → 161

bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

NC_049285.1 Alternate UMICH_Zoey_3.1

Range

24249725..24252576 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038510149.1 → XP_038366077.1 heart- and neural crest derivatives-expressed protein 2

Conserved Domains (1) summary

cd11471
Location:100 → 161

bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049766.1 Alternate UNSW_CanFamBas_1.0

Range

24141364..24144207 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038637914.1 → XP_038493842.1 heart- and neural crest derivatives-expressed protein 2

Conserved Domains (1) summary

cd11471
Location:100 → 161

bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049246.1 Alternate UU_Cfam_GSD_1.0

Range

24290187..24293030 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038573605.1 → XP_038429533.1 heart- and neural crest derivatives-expressed protein 2

UniProtKB/TrEMBL

A0A8C0KHD4, A0A8C0P2Z2, A0A8I3PA17

Conserved Domains (1) summary

cd11471
Location:100 → 161

bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

24791105..24793938 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022410028.2 → XP_022265736.2 heart- and neural crest derivatives-expressed protein 2

UniProtKB/TrEMBL

A0A8C0KHD4, A0A8C0P2Z2, A0A8I3PA17

Conserved Domains (1) summary

cd11471
Location:100 → 161

bHLH_TS_HAND2; basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins