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TRAPPC11 trafficking protein particle complex 11 [ Homo sapiens (human) ]

Gene ID: 60684, updated on 4-Nov-2018

Summary

Official Symbol
TRAPPC11provided by HGNC
Official Full Name
trafficking protein particle complex 11provided by HGNC
Primary source
HGNC:HGNC:25751
See related
Ensembl:ENSG00000168538 MIM:614138; Vega:OTTHUMG00000160673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRY; FOIGR; LGMD2S; C4orf41; LGMDR18
Summary
The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in adrenal (RPKM 9.6), thyroid (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See TRAPPC11 in Genome Data Viewer
Location:
4q35.1
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (183659267..183713594)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184580420..184634747)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377580 Neighboring gene uncharacterized LOC107986329 Neighboring gene RNA, U6 small nuclear 479, pseudogene Neighboring gene RWD domain containing 4 Neighboring gene RNA, U6 small nuclear 335, pseudogene Neighboring gene RNA, U6 small nuclear 1053, pseudogene Neighboring gene uncharacterized LOC105377581 Neighboring gene storkhead box 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
    RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemHuman cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of d...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12716

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein complex stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
TRAPP complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
trafficking protein particle complex subunit 11
Names
foie gras homolog
gryzun homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033102.1 RefSeqGene

    Range
    5001..59328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021942.5NP_068761.4  trafficking protein particle complex subunit 11 isoform a

    See identical proteins and their annotated locations for NP_068761.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI034264, BX647127, BX648499, DB096222
    Consensus CDS
    CCDS34112.1
    UniProtKB/Swiss-Prot
    Q7Z392
    Related
    ENSP00000335371.6, OTTHUMP00000218691, ENST00000334690.10, OTTHUMT00000361654
    Conserved Domains (2) summary
    pfam12742
    Location:10361095
    Gryzun-like; Gryzun, putative Golgi trafficking
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1
  2. NM_199053.2NP_951008.1  trafficking protein particle complex subunit 11 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI034264, BC051724, BX648499, DB096222
    Consensus CDS
    CCDS47166.1
    UniProtKB/Swiss-Prot
    Q7Z392
    Related
    ENSP00000349738.4, ENST00000357207.8
    Conserved Domains (2) summary
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1
    pfam12742
    Location:10361066
    Gryzun-like; Gryzun, putative Golgi trafficking

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    183659267..183713594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008537.2XP_016864026.1  trafficking protein particle complex subunit 11 isoform X2

  2. XM_017008538.2XP_016864027.1  trafficking protein particle complex subunit 11 isoform X3

  3. XM_024454180.1XP_024309948.1  trafficking protein particle complex subunit 11 isoform X1

    Conserved Domains (2) summary
    pfam12742
    Location:10361095
    Gryzun-like; Gryzun, putative Golgi trafficking
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1
  4. XM_024454181.1XP_024309949.1  trafficking protein particle complex subunit 11 isoform X4

    Related
    ENSP00000421004.1, ENST00000512476.1
    Conserved Domains (2) summary
    pfam12742
    Location:586645
    Gryzun-like; Gryzun, putative Golgi trafficking
    pfam11817
    Location:172
    Foie-gras_1; Foie gras liver health family 1
  5. XM_024454179.1XP_024309947.1  trafficking protein particle complex subunit 11 isoform X1

    Conserved Domains (2) summary
    pfam12742
    Location:10361095
    Gryzun-like; Gryzun, putative Golgi trafficking
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1

RNA

  1. XR_001741315.2 RNA Sequence

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