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TRAPPC11 trafficking protein particle complex subunit 11 [ Homo sapiens (human) ]

Gene ID: 60684, updated on 10-Oct-2023

Summary

Official Symbol
TRAPPC11provided by HGNC
Official Full Name
trafficking protein particle complex subunit 11provided by HGNC
Primary source
HGNC:HGNC:25751
See related
Ensembl:ENSG00000168538 MIM:614138; AllianceGenome:HGNC:25751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRY; FOIGR; LGMD2S; C4orf41; LGMDR18
Summary
The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in adrenal (RPKM 9.6), thyroid (RPKM 9.5) and 25 other tissues See more
Orthologs
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Genomic context

See TRAPPC11 in Genome Data Viewer
Location:
4q35.1
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (183659293..183713589)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (187002489..187056786)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184580446..184634742)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22185 Neighboring gene RWD domain containing 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:184579545-184580333 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:184580334-184581121 Neighboring gene RNA, U6 small nuclear 479, pseudogene Neighboring gene RNA, U6 small nuclear 335, pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:184614366-184615565 Neighboring gene RNA, U6 small nuclear 1053, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:184644336-184645097 Neighboring gene uncharacterized LOC105377581 Neighboring gene uncharacterized LOC124900824

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12716

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
part_of TRAPP complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of TRAPPIII protein complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
trafficking protein particle complex subunit 11
Names
foie gras homolog
gryzun homolog
trafficking protein particle complex 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033102.1 RefSeqGene

    Range
    5027..59323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021942.6NP_068761.4  trafficking protein particle complex subunit 11 isoform a

    See identical proteins and their annotated locations for NP_068761.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI034264, BX647127, BX648499
    Consensus CDS
    CCDS34112.1
    UniProtKB/Swiss-Prot
    A4QPB8, B2RCD6, Q5U5I7, Q6FI73, Q7Z392, Q86T25, Q9H0L1, Q9H5K9, Q9H8Q1, Q9H9I7
    UniProtKB/TrEMBL
    B3KU05
    Related
    ENSP00000335371.6, ENST00000334690.11
    Conserved Domains (2) summary
    pfam12742
    Location:10361095
    Gryzun-like; Gryzun, putative Golgi trafficking
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1
  2. NM_199053.3NP_951008.1  trafficking protein particle complex subunit 11 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains alternate exon structure in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC051724, BX648499
    Consensus CDS
    CCDS47166.1
    UniProtKB/TrEMBL
    B3KU05
    Related
    ENSP00000349738.4, ENST00000357207.8
    Conserved Domains (2) summary
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1
    pfam12742
    Location:10361066
    Gryzun-like; Gryzun, putative Golgi trafficking

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    183659293..183713589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454180.2XP_024309948.1  trafficking protein particle complex subunit 11 isoform X1

    UniProtKB/Swiss-Prot
    A4QPB8, B2RCD6, Q5U5I7, Q6FI73, Q7Z392, Q86T25, Q9H0L1, Q9H5K9, Q9H8Q1, Q9H9I7
    UniProtKB/TrEMBL
    B3KU05
    Conserved Domains (2) summary
    pfam12742
    Location:10361095
    Gryzun-like; Gryzun, putative Golgi trafficking
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1
  2. XM_047416069.1XP_047272025.1  trafficking protein particle complex subunit 11 isoform X2

    UniProtKB/TrEMBL
    B3KU05
  3. XM_024454179.2XP_024309947.1  trafficking protein particle complex subunit 11 isoform X1

    UniProtKB/Swiss-Prot
    A4QPB8, B2RCD6, Q5U5I7, Q6FI73, Q7Z392, Q86T25, Q9H0L1, Q9H5K9, Q9H8Q1, Q9H9I7
    UniProtKB/TrEMBL
    B3KU05
    Conserved Domains (2) summary
    pfam12742
    Location:10361095
    Gryzun-like; Gryzun, putative Golgi trafficking
    pfam11817
    Location:263522
    Foie-gras_1; Foie gras liver health family 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    187002489..187056786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350702.1XP_054206677.1  trafficking protein particle complex subunit 11 isoform X1

    UniProtKB/Swiss-Prot
    A4QPB8, B2RCD6, Q5U5I7, Q6FI73, Q7Z392, Q86T25, Q9H0L1, Q9H5K9, Q9H8Q1, Q9H9I7
    UniProtKB/TrEMBL
    B3KU05
  2. XM_054350703.1XP_054206678.1  trafficking protein particle complex subunit 11 isoform X2

    UniProtKB/TrEMBL
    B3KU05
  3. XM_054350701.1XP_054206676.1  trafficking protein particle complex subunit 11 isoform X1

    UniProtKB/Swiss-Prot
    A4QPB8, B2RCD6, Q5U5I7, Q6FI73, Q7Z392, Q86T25, Q9H0L1, Q9H5K9, Q9H8Q1, Q9H9I7
    UniProtKB/TrEMBL
    B3KU05