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MIIP migration and invasion inhibitory protein [ Homo sapiens (human) ]

Gene ID: 60672, updated on 7-Jun-2020

Summary

Official Symbol
MIIPprovided by HGNC
Official Full Name
migration and invasion inhibitory proteinprovided by HGNC
Primary source
HGNC:HGNC:25715
See related
Ensembl:ENSG00000116691 MIM:608772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IIP45
Summary
This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 8.7) and 24 other tissues See more
Orthologs

Genomic context

See MIIP in Genome Data Viewer
Location:
1p36.22
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (12019466..12032045)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12079299..12092106)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8260 Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Neighboring gene mitofusin 2 Neighboring gene microRNA 6729 Neighboring gene CRISPRi-validated cis-regulatory element chr1.1957 Neighboring gene RNA, 7SL, cytoplasmic 649, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef-mediated downregulation of HLA (MHCI) may be affected by/inhibited by' MIIP as demonstrated by siRNA genome-wide screen [in HeLa cells) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12438, FLJ38609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
migration and invasion-inhibitory protein
Names
IGFBP2-binding protein
invasion-inhibitory protein 45

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030022.2 RefSeqGene

    Range
    5257..17804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021933.4NP_068752.2  migration and invasion-inhibitory protein

    See identical proteins and their annotated locations for NP_068752.2

    Status: REVIEWED

    Source sequence(s)
    FJ618905
    Consensus CDS
    CCDS143.1
    UniProtKB/Swiss-Prot
    Q5JXC2
    Related
    ENSP00000235332.4, ENST00000235332.6
    Conserved Domains (1) summary
    pfam15734
    Location:66378
    MIIP; Migration and invasion-inhibitory

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    12019466..12032045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263487.4XP_005263544.1  migration and invasion-inhibitory protein isoform X2

    Conserved Domains (1) summary
    pfam15734
    Location:66366
    MIIP; Migration and invasion-inhibitory
  2. XM_011541896.1XP_011540198.1  migration and invasion-inhibitory protein isoform X1

    See identical proteins and their annotated locations for XP_011540198.1

    UniProtKB/Swiss-Prot
    Q5JXC2
    Conserved Domains (1) summary
    pfam15734
    Location:66378
    MIIP; Migration and invasion-inhibitory
  3. XM_011541895.1XP_011540197.1  migration and invasion-inhibitory protein isoform X1

    See identical proteins and their annotated locations for XP_011540197.1

    UniProtKB/Swiss-Prot
    Q5JXC2
    Conserved Domains (1) summary
    pfam15734
    Location:66378
    MIIP; Migration and invasion-inhibitory

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025374.1: Suppressed sequence

    Description
    NM_001025374.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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