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MIIP migration and invasion inhibitory protein [ Homo sapiens (human) ]

Gene ID: 60672, updated on 3-Dec-2023

Summary

Official Symbol
MIIPprovided by HGNC
Official Full Name
migration and invasion inhibitory proteinprovided by HGNC
Primary source
HGNC:HGNC:25715
See related
Ensembl:ENSG00000116691 MIM:608772; AllianceGenome:HGNC:25715
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IIP45
Summary
This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 8.7) and 24 other tissues See more
Orthologs
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Genomic context

See MIIP in Genome Data Viewer
Location:
1p36.22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12019498..12032045)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11563622..11576189)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12079555..12092102)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11994483-11995406 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:11998825-12000024 Neighboring gene Sharpr-MPRA regulatory region 8260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12005168-12005843 Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12023296-12023497 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12026474-12026974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12026975-12027475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12060855-12061784 Neighboring gene mitofusin 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12065587-12065864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12067964-12068629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12068630-12069294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12079342-12080212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12080213-12081083 Neighboring gene CRISPRi-validated cis-regulatory element chr1.1957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 188 Neighboring gene microRNA 6729 Neighboring gene RNA, 7SL, cytoplasmic 649, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 197 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12122803-12123035 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 199 Neighboring gene TNF receptor superfamily member 8 Neighboring gene RNA, U6 small nuclear 777, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef-mediated downregulation of HLA (MHCI) may be affected by/inhibited by' MIIP as demonstrated by siRNA genome-wide screen [in HeLa cells) PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
migration and invasion-inhibitory protein
Names
IGFBP2-binding protein
invasion-inhibitory protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030022.2 RefSeqGene

    Range
    5257..17804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021933.4NP_068752.2  migration and invasion-inhibitory protein

    See identical proteins and their annotated locations for NP_068752.2

    Status: REVIEWED

    Source sequence(s)
    FJ618905
    Consensus CDS
    CCDS143.1
    UniProtKB/Swiss-Prot
    C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
    Related
    ENSP00000235332.4, ENST00000235332.6
    Conserved Domains (1) summary
    pfam15734
    Location:66378
    MIIP; Migration and invasion-inhibitory

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    12019498..12032045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541895.2XP_011540197.1  migration and invasion-inhibitory protein isoform X1

    See identical proteins and their annotated locations for XP_011540197.1

    UniProtKB/Swiss-Prot
    C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
    Conserved Domains (1) summary
    pfam15734
    Location:66378
    MIIP; Migration and invasion-inhibitory
  2. XM_011541896.2XP_011540198.1  migration and invasion-inhibitory protein isoform X1

    See identical proteins and their annotated locations for XP_011540198.1

    UniProtKB/Swiss-Prot
    C0KL22, Q5JXC2, Q96HU6, Q9H839, Q9HA00
    Conserved Domains (1) summary
    pfam15734
    Location:66378
    MIIP; Migration and invasion-inhibitory
  3. XM_005263487.5XP_005263544.1  migration and invasion-inhibitory protein isoform X2

    Conserved Domains (1) summary
    pfam15734
    Location:66366
    MIIP; Migration and invasion-inhibitory

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    11563622..11576189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338078.1XP_054194053.1  migration and invasion-inhibitory protein isoform X2

  2. XM_054338077.1XP_054194052.1  migration and invasion-inhibitory protein isoform X1

  3. XM_054338076.1XP_054194051.1  migration and invasion-inhibitory protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025374.1: Suppressed sequence

    Description
    NM_001025374.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.