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Pgap6 post-glycosylphosphatidylinositol attachment to proteins 6 [ Mus musculus (house mouse) ]

Gene ID: 60455, updated on 24-Jan-2023


Official Symbol
Pgap6provided by MGI
Official Full Name
post-glycosylphosphatidylinositol attachment to proteins 6provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000024180 AllianceGenome:MGI:1926283
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M83; Tmem8; Rxylt1; Tmem8a; GPI-PLA2
Predicted to enable phospholipase A2 activity. Predicted to be located in lysosome and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in cranial ganglion; genitourinary system; gut; lung; and olfactory epithelium. Orthologous to human PGAP6 (post-glycosylphosphatidylinositol attachment to proteins 6). [provided by Alliance of Genome Resources, Apr 2022]
Biased expression in kidney adult (RPKM 98.6), testis adult (RPKM 76.1) and 14 other tissues See more
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Genomic context

See Pgap6 in Genome Data Viewer
17; 17 A3.3
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26332290..26342228)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26112752..26123254)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene axin 1

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information



Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
enables molecular_function ND
No biological Data available
more info
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
located_in plasma membrane NAS
Non-traceable Author Statement
more info

General protein information

Preferred Names
post-GPI attachment to proteins factor 6
GPI processing phospholipase A2
ribitol xylosyltransferase 1
transmembrane protein 6
transmembrane protein 8 (five membrane-spanning domains)
transmembrane protein 8A
type I transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021793.2NP_068565.1  post-GPI attachment to proteins factor 6 precursor

    See identical proteins and their annotated locations for NP_068565.1

    Status: VALIDATED

    Source sequence(s)
    AC140047, AK044384, BP766233
    Consensus CDS
    Q99JS5, Q9ESN3
    ENSMUSP00000025010.8, ENSMUST00000025010.14
    Conserved Domains (1) summary
    DUF3522; Protein of unknown function (DUF3522)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000083.7 Reference GRCm39 C57BL/6J

    GenBank, FASTA, Sequence Viewer (Graphics)