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PGAP6 post-GPI attachment to proteins 6 [ Homo sapiens (human) ]

Gene ID: 58986, updated on 22-Sep-2022

Summary

Official Symbol
PGAP6provided by HGNC
Official Full Name
post-GPI attachment to proteins 6provided by HGNC
Primary source
HGNC:HGNC:17205
See related
Ensembl:ENSG00000129925 MIM:619342; AllianceGenome:HGNC:17205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M83; TMEM6; TMEM8; TMEM8A; GPI-PLA2
Summary
Predicted to enable phospholipase A2 activity. Located in extracellular exosome and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 24.1), placenta (RPKM 22.5) and 25 other tissues See more
Orthologs
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Genomic context

See PGAP6 in Genome Data Viewer
Location:
16p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (370788..386979, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (366436..377866, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (420788..431978, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene axin 1 Neighboring gene Sharpr-MPRA regulatory region 4309 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene uncharacterized LOC100134368 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene 2,4-dienoyl-CoA reductase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
post-GPI attachment to proteins factor 6
Names
GPI processing phospholipase A2
five-span transmembrane protein M83
post-glycosylphosphatidylinositol attachment to proteins 6
transmembrane protein 6
transmembrane protein 8 (five membrane-spanning domains)
transmembrane protein 8A
NP_067082.2
XP_047290369.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021259.3NP_067082.2  post-GPI attachment to proteins factor 6 precursor

    See identical proteins and their annotated locations for NP_067082.2

    Status: VALIDATED

    Source sequence(s)
    AB045292, AI678371, AL537021, AL546643, BC004276, BC021557, DB224383, Z97634
    Consensus CDS
    CCDS10407.1
    UniProtKB/Swiss-Prot
    Q9H7B9, Q9HCN3
    Related
    ENSP00000401338.2, ENST00000431232.7
    Conserved Domains (1) summary
    pfam12036
    Location:547727
    DUF3522; Protein of unknown function (DUF3522)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    370788..386979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434413.1XP_047290369.1  post-GPI attachment to proteins factor 6 isoform X1

    UniProtKB/TrEMBL
    K4DI83
    Related
    ENSP00000250930.3, ENST00000250930.7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    366436..377866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)