U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Iigp1 interferon inducible GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 60440, updated on 18-Apr-2024

Summary

Official Symbol
Iigp1provided by MGI
Official Full Name
interferon inducible GTPase 1provided by MGI
Primary source
MGI:MGI:1926259
See related
Ensembl:ENSMUSG00000054072 AllianceGenome:MGI:1926259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iigp; Irga6; Ifgga1; 2900074L10Rik
Summary
Enables GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in defense response to Gram-negative bacterium; defense response to protozoan; and regulation of autophagy. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Located in endoplasmic reticulum membrane and symbiont-containing vacuole membrane. Is expressed in several structures, including cardiovascular system; foregut; genitourinary system; limb; and respiratory system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 22.2), liver adult (RPKM 9.9) and 4 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
18 D3; 18 34.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60506688..60525706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60373616..60392634)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene immunity-related GTPase pseudogene Neighboring gene interferon inducible GTPase 1 pseudogene Neighboring gene predicted pseudogene 6960 Neighboring gene interferon-inducible GTPase-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-inducible GTPase 1
Names
interferon-gamma-inducible GTPase Ifgga1 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146275.1NP_001139747.1  interferon-inducible GTPase 1

    See identical proteins and their annotated locations for NP_001139747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC151990, AF194871, AJ007971, AK153060, DV061261
    Consensus CDS
    CCDS29270.1
    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Related
    ENSMUSP00000032473.7, ENSMUST00000032473.7
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)
  2. NM_021792.5NP_068564.4  interferon-inducible GTPase 1

    See identical proteins and their annotated locations for NP_068564.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC151990, AF194871, AJ007971, AK153060
    Consensus CDS
    CCDS29270.1
    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60506688..60525706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246978.4XP_011245280.1  interferon-inducible GTPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245280.1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)
  2. XM_011246980.3XP_011245282.1  interferon-inducible GTPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245282.1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)
  3. XM_030250557.2XP_030106417.1  interferon-inducible GTPase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Related
    ENSMUSP00000063390.6, ENSMUST00000066912.13
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)
  4. XM_011246979.4XP_011245281.1  interferon-inducible GTPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245281.1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)
  5. XM_030250559.2XP_030106419.1  interferon-inducible GTPase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)
  6. XM_036161227.1XP_036017120.1  interferon-inducible GTPase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Related
    ENSMUSP00000157568.2, ENSMUST00000237185.2
    Conserved Domains (1) summary
    pfam05049
    Location:35409
    IIGP; Interferon-inducible GTPase (IIGP)