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Iigp1 interferon inducible GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 60440, updated on 14-May-2024

Summary

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Official Symbol
Iigp1provided by MGI
Official Full Name
interferon inducible GTPase 1provided by MGI
Primary source
MGI:MGI:1926259
See related
Ensembl:ENSMUSG00000054072 AllianceGenome:MGI:1926259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Iigp; Irga6; Ifgga1; 2900074L10Rik
Summary
Enables GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in defense response to Gram-negative bacterium; defense response to protozoan; and regulation of autophagy. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Located in endoplasmic reticulum membrane and symbiont-containing vacuole membrane. Is expressed in several structures, including cardiovascular system; foregut; genitourinary system; limb; and respiratory system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 22.2), liver adult (RPKM 9.9) and 4 other tissues See more
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Genomic context

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See Iigp1 in Genome Data Viewer
Location:
18 D3; 18 34.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60506688..60525706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60373616..60392634)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene immunity-related GTPase pseudogene Neighboring gene interferon inducible GTPase 1 pseudogene Neighboring gene predicted pseudogene 6960 Neighboring gene interferon-inducible GTPase-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion. Schulte K, et al. BMC Biol, 2016 Mar 2. PMID 26934976, Free PMC Article
  2. The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7. Hermanns T, et al. Cell Microbiol, 2016 Feb. PMID 26247512, Free PMC Article
  3. The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases. Reese ML, et al. J Biol Chem, 2014 Oct 3. PMID 25118287, Free PMC Article
  4. A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins. Fleckenstein MC, et al. PLoS Biol, 2012. PMID 22802726, Free PMC Article
  5. The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens. Liesenfeld O, et al. PLoS One, 2011. PMID 21698150, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication.
    Title: Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication.
  2. The study determined the crystal structure of an oligomerization-impaired Irga6 mutant bound to a non-hydrolyzable GTP analog.
    Title: The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion.
  3. These data identify Toxoplasma gondii GRA7 as a regulator for ROP18-specific inactivation of murine Irga6.
    Title: The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.
  4. ROP5 uses a highly polymorphic surface to bind adjacent to the nucleotide-binding domain of an IRG and that this produces a profound allosteric change in the IRGa6 structure. [Rop5]
    Title: The Toxoplasma pseudokinase ROP5 is an allosteric inhibitor of the immunity-related GTPases.
  5. This study defines the catalytic G-domain interface by mutagenesis and presents a model of how GTP hydrolysis is activated in Irga6 complexes, based on the substrate-twinning reaction mechanism of the signal recognition particle and its receptor (SRalpha).
    Title: The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.
  6. Toxoplasma gondii ROP5 binding alters the conformation of the Irga6 active site.
    Title: A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.
  7. results implicate Irga6 in the control of infection with T. gondii and further highlight the importance of the IRG system for resistance to this pathogen
    Title: The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.
  8. Virulent T. gondii strain ROP18 kinase phosphorylates host Irga6 at two threonines in the nucleotide-binding domain, biochemically inactivating the GTPase and inhibiting its accumulation and action at the T. gondii parasitophorous vacuole membrane.
    Title: Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.
  9. role of constitutive hepatocyte expression of Irga6 in resistance to parasites invading from the gut via the hepatic portal system
    Title: A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
  10. Differential induction by various gram-negative lipopolysaccharides was myeloid differentiation factor 88 (MyD88)-independent
    Title: Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interferon-inducible GTPase 1
Names
interferon-gamma-inducible GTPase Ifgga1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146275.1 → NP_001139747.1  interferon-inducible GTPase 1

    See identical proteins and their annotated locations for NP_001139747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC151990, AF194871, AJ007971, AK153060, DV061261
    Consensus CDS
    CCDS29270.1
    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Related
    ENSMUSP00000032473.7, ENSMUST00000032473.7
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)

  2. NM_021792.5 → NP_068564.4  interferon-inducible GTPase 1

    See identical proteins and their annotated locations for NP_068564.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC151990, AF194871, AJ007971, AK153060
    Consensus CDS
    CCDS29270.1
    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    60506688..60525706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246978.4 → XP_011245280.1  interferon-inducible GTPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245280.1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)

  2. XM_011246980.3 → XP_011245282.1  interferon-inducible GTPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245282.1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)

  3. XM_030250557.2 → XP_030106417.1  interferon-inducible GTPase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Related
    ENSMUSP00000063390.6, ENSMUST00000066912.13
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)

  4. XM_011246979.4 → XP_011245281.1  interferon-inducible GTPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245281.1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)

  5. XM_030250559.2 → XP_030106419.1  interferon-inducible GTPase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)

  6. XM_036161227.1 → XP_036017120.1  interferon-inducible GTPase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9QZ85, Q9Z1M3
    UniProtKB/TrEMBL
    J7NNX8, U5NG72
    Related
    ENSMUSP00000157568.2, ENSMUST00000237185.2
    Conserved Domains (1) summary
    pfam05049
    Location:35 → 409
    IIGP; Interferon-inducible GTPase (IIGP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ85.2 GenPept UniProtKB/Swiss-Prot:Q9QZ85

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