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RNASE6 ribonuclease A family member k6 [ Homo sapiens (human) ]

Gene ID: 6039, updated on 21-Dec-2019

Summary

Official Symbol
RNASE6provided by HGNC
Official Full Name
ribonuclease A family member k6provided by HGNC
Primary source
HGNC:HGNC:10048
See related
Ensembl:ENSG00000169413 MIM:601981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAD1; RNS6; RNasek6
Summary
The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]
Expression
Broad expression in lymph node (RPKM 33.5), appendix (RPKM 26.6) and 24 other tissues See more
Orthologs

Genomic context

See RNASE6 in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20780956..20782467)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21249210..21250626)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984671 Neighboring gene epididymal protein 3A Neighboring gene epididymal protein 3D, pseudogene Neighboring gene epididymal protein 3B Neighboring gene uncharacterized LOC105370397 Neighboring gene ribonuclease A family member 1, pancreatic Neighboring gene Sharpr-MPRA regulatory region 8185

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of ribonuclease K6 (RNASE6) in human B cells PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of RNase A ribonuclease k6 (RNASE6) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonuclease K6
Names
ribonuclease A D1
ribonuclease, RNase A family, k6
testicular tissue protein Li 166
NP_005606.1
XP_016877055.1
XP_016877056.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005615.5NP_005606.1  ribonuclease K6 precursor

    See identical proteins and their annotated locations for NP_005606.1

    Status: REVIEWED

    Source sequence(s)
    AI151384, BC020848
    Consensus CDS
    CCDS9558.1
    UniProtKB/Swiss-Prot
    Q93091
    UniProtKB/TrEMBL
    Q6IB39
    Related
    ENSP00000302046.2, ENST00000304677.3
    Conserved Domains (1) summary
    pfam00074
    Location:31147
    RnaseA; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20780956..20782467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021567.1XP_016877056.1  ribonuclease K6 isoform X1

    UniProtKB/Swiss-Prot
    Q93091
    UniProtKB/TrEMBL
    Q6IB39
    Conserved Domains (1) summary
    pfam00074
    Location:31147
    RnaseA; Pancreatic ribonuclease
  2. XM_017021566.1XP_016877055.1  ribonuclease K6 isoform X1

    UniProtKB/Swiss-Prot
    Q93091
    UniProtKB/TrEMBL
    Q6IB39
    Conserved Domains (1) summary
    pfam00074
    Location:31147
    RnaseA; Pancreatic ribonuclease
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