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RNASE1 ribonuclease A family member 1, pancreatic [ Homo sapiens (human) ]

Gene ID: 6035, updated on 7-Dec-2018

Summary

Official Symbol
RNASE1provided by HGNC
Official Full Name
ribonuclease A family member 1, pancreaticprovided by HGNC
Primary source
HGNC:HGNC:10044
See related
Ensembl:ENSG00000129538 MIM:180440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAC1; RIB1; RNS1
Summary
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in pancreas (RPKM 931.1), testis (RPKM 410.8) and 19 other tissues See more
Orthologs

Genomic context

See RNASE1 in Genome Data Viewer
Location:
14q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (20801356..20802877, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21269515..21271036, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984671 Neighboring gene epididymal protein 3B Neighboring gene uncharacterized LOC105370397 Neighboring gene ribonuclease A family member k6 Neighboring gene uncharacterized LOC100507513 Neighboring gene ribonuclease A family member 3 Neighboring gene ribonuclease A family member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with ribonuclease, RNase A family, 1 (RNASE1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of RNase A ribonuclease 1 (RNASE1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease A activity IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
NOT defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 

General protein information

Preferred Names
ribonuclease pancreatic
Names
HP-RNase
RIB-1
RNase 1
RNase A
RNase upI-1
ribonuclease 1
ribonuclease A C1
ribonuclease, RNase A family, 1 (pancreatic)
NP_002924.1
NP_937875.1
NP_937877.1
NP_937878.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002933.5NP_002924.1  ribonuclease pancreatic precursor

    See identical proteins and their annotated locations for NP_002924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is the predominant transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL133371, BC005324, BP385178
    Consensus CDS
    CCDS9559.1
    UniProtKB/Swiss-Prot
    P07998
    UniProtKB/TrEMBL
    W0UV93
    Related
    ENSP00000381057.4, ENST00000397967.4
    Conserved Domains (1) summary
    smart00092
    Location:29152
    RNAse_Pc; Pancreatic ribonuclease
  2. NM_198232.2NP_937875.1  ribonuclease pancreatic precursor

    See identical proteins and their annotated locations for NP_937875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes a different segment in the 5' UTR compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AI400223, BI753463
    Consensus CDS
    CCDS9559.1
    UniProtKB/Swiss-Prot
    P07998
    UniProtKB/TrEMBL
    W0UV93
    Related
    ENSP00000399493.2, ENST00000412779.2
    Conserved Domains (1) summary
    smart00092
    Location:29152
    RNAse_Pc; Pancreatic ribonuclease
  3. NM_198234.2NP_937877.1  ribonuclease pancreatic precursor

    See identical proteins and their annotated locations for NP_937877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in the 5' UTR compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AV710596, BC005324, BP385178
    Consensus CDS
    CCDS9559.1
    UniProtKB/Swiss-Prot
    P07998
    UniProtKB/TrEMBL
    W0UV93
    Related
    ENSP00000344193.3, ENST00000340900.3
    Conserved Domains (1) summary
    smart00092
    Location:29152
    RNAse_Pc; Pancreatic ribonuclease
  4. NM_198235.2NP_937878.1  ribonuclease pancreatic precursor

    See identical proteins and their annotated locations for NP_937878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an additional segment in the 5' UTR compared to variant 4. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK098375, BC005324, BC022882, BP385178
    Consensus CDS
    CCDS9559.1
    UniProtKB/Swiss-Prot
    P07998
    UniProtKB/TrEMBL
    W0UV93
    Related
    ENSP00000381060.4, ENST00000397970.4
    Conserved Domains (1) summary
    smart00092
    Location:29152
    RNAse_Pc; Pancreatic ribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    20801356..20802877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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