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RFC4 replication factor C subunit 4 [ Homo sapiens (human) ]

Gene ID: 5984, updated on 28-Nov-2021

Summary

Official Symbol
RFC4provided by HGNC
Official Full Name
replication factor C subunit 4provided by HGNC
Primary source
HGNC:HGNC:9972
See related
Ensembl:ENSG00000163918 MIM:102577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A1; RFC37
Summary
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 108.6), ovary (RPKM 88.0) and 25 other tissues See more
Orthologs
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Genomic context

See RFC4 in Genome Data Viewer
Location:
3q27.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (186789900..186806482, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186507689..186524271, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene small nucleolar RNA, H/ACA box 63 Neighboring gene small nucleolar RNA, H/ACA box 4 Neighboring gene long intergenic non-protein coding RNA 2043 Neighboring gene adiponectin enhancer region Neighboring gene adiponectin, C1Q and collagen domain containing Neighboring gene ADIPOQ antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of replication factor C, subunit 4 (RFC4, 37kDa) in the nucleoli of Jurkat T-cells PubMed
tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes RFC, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27291

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to DNA clamp loader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to single-stranded DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA strand elongation involved in DNA replication TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA-dependent DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of DNA replication factor C complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Elg1 RFC-like complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
replication factor C subunit 4
Names
A1 37 kDa subunit
RF-C 37 kDa subunit
RFC 37 kDa subunit
activator 1 37 kDa subunit
activator 1 subunit 4
replication factor C (activator 1) 4, 37kDa
replication factor C 37 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002916.5NP_002907.1  replication factor C subunit 4

    See identical proteins and their annotated locations for NP_002907.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA521171, AC112907, BC017452, DA359927
    Consensus CDS
    CCDS3283.1
    UniProtKB/Swiss-Prot
    P35249
    Related
    ENSP00000296273.2, ENST00000296273.7
    Conserved Domains (1) summary
    cl25702
    Location:39353
    Rad17; Rad17 cell cycle checkpoint protein
  2. NM_181573.3NP_853551.1  replication factor C subunit 4

    See identical proteins and their annotated locations for NP_853551.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA521171, AC112907, CX788139
    Consensus CDS
    CCDS3283.1
    UniProtKB/Swiss-Prot
    P35249
    Related
    ENSP00000376272.2, ENST00000392481.6
    Conserved Domains (1) summary
    cl25702
    Location:39353
    Rad17; Rad17 cell cycle checkpoint protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    186789900..186806482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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